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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
A facile route to phenyl, phenylsulfanyl and phenylselanyl substituted pyrano[3,2-c]chromenes
Tetrahedron, Volume 66, No. 6, Year 2010
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Description
The synthesis of phenyl, phenylsulfanyl and phenylselanyl substituted pyrano[3,2-c]chromenes 4 is accomplished via cyclocondensation of 4-oxo-4H-chromen-3-carbaldehydes 1 with appropriately substituted acetic acids 2 under mild conditions. Further treatment of 4 with alcohol or water led to 5-alkoxy- and 5-hydroxy-2H,5H-pyrano[3,2-c]chromen-2-ones 5 and 6, respectively. Acid and thermal catalysed rearrangement of 4-6 gave 5-hydroxypyrano[2,3-b]chromen-2(10aH)-ones 7 and their subsequent substitution led to 5-alkoxyderivatives 8. Reaction of 4 with amides led to 5-acylamino or 5-phenylsulfonamino substituted 2H,5H-pyrano[3,2-c]chromen-2-ones 9. Reactions were performed under heating or microwave irradiation. © 2009.
Authors & Co-Authors
Lacová, Margita
Slovakia, Bratislava
Univerzita Komenského V Bratislave
Gašparová, Renata
Slovakia, Trnava
University of ss Cyril and Methodius, Trnava
Koiš, Pavol
Slovakia, Bratislava
Univerzita Komenského V Bratislave
Boháč, Andrej
Slovakia, Bratislava
Univerzita Komenského V Bratislave
El-Shaaer, Hafez Mohamed
Egypt, Cairo
College of Science
Statistics
Citations: 21
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.tet.2009.11.057
Research Areas
Environmental
Substance Abuse