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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
BMI in relation to sperm count: An updated systematic review and collaborative meta-analysis
Human Reproduction Update, Volume 19, No. 3, Year 2013
Notification
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Description
Background: The global obesity epidemic has paralleled a decrease in semen quality. Yet, the association between obesity and sperm parameters remains controversial. The purpose of this report was to update the evidence on the association between BMI and sperm count through a systematic review with meta-analysis. Methods: A systematic review of available literature (with no language restriction) was performed to investigate the impact of BMI on sperm count. Relevant studies published until June 2012 were identified from a Pubmed and EMBASE search. We also included unpublished data (n =717 men) obtained from the Infertility Center of Bondy, France. Abstracts of relevant articles were examined and studies that could be included in this review were retrieved. Authors of relevant studies for the meta-analysis were contacted by email and asked to provide standardized data. Results: A total of 21 studies were included in the meta-analysis, resulting in a sample of 13 077 men from the general population and attending fertility clinics. Data were stratified according to the total sperm count as normozoospermia, oligozoospermia and azoospermia. Standardized weighted mean differences in sperm concentration did not differ significantly across BMI categories. There was a J-shaped relationship between BMI categories and risk of oligozoospermia or azoospermia. Compared with men of normal weight, the odds ratio (95% confidence interval) for oligozoospermia or azoospermia was 1.15 (0.93-1.43) for underweight, 1.11 (1.01-1.21) for overweight, 1.28 (1.06-1.55) for obese and 2.04 (1.59-2.62) for morbidly obese men. Conclusions: Overweight and obesity were associated with an increased prevalence of azoospermia or oligozoospermia. The main limitation of this report is that studied populations varied, with men recruited from both the general population and infertile couples. Whether weight normalization could improve sperm parameters should be evaluated further. © The Author 2012. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
Authors & Co-Authors
Sermondade, Nathalie
France, Bondy
Hopital Jean-verdier
France, Bobigny
Équipe de Recherche en Épidémiologie Nutritionnelle Eren
Faure, Céline
France, Bondy
Hopital Jean-verdier
France, Bobigny
Équipe de Recherche en Épidémiologie Nutritionnelle Eren
Fézeu, Léopold K.
France, Bobigny
Équipe de Recherche en Épidémiologie Nutritionnelle Eren
Shayeb, A. G.
United Kingdom, Cardiff
University Hospital of Wales
Bonde, Jens Peter Ellekilde
Denmark, Copenhagen
Bispebjerg Hospital
Jensen, Tina Kold
Denmark, Copenhagen
Rigshospitalet
Van Wely, Madelon
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Cao, Jia
China, Chongqing
Third Military Medical University
Martini, Ana Carolina
Argentina, Cordoba
Universidad Nacional de Cordoba, Facultad de Ciencias Medicas
Eskandar, Mamdoh A.
Saudi Arabia, Abha
College of Medicine
Chavarro, Jorge E.
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Boston
Brigham and Women's Hospital
Koloszár, Sándor
Hungary, Szeged
Szegedi Tudományegyetem Általános Orvostudományi Kar
Twigt, J. M.
Netherlands, Rotterdam
Erasmus Mc
Ramlau-Hansen, Cecilia Høst
Denmark, Aarhus
Aarhus Universitet
Borges, Edson
Brazil, Sao Paulo
Fertility-assisted Fertilization Center
Lotti, Francesco
Italy, Florence
Università Degli Studi Di Firenze
Steegers-Theunissen, Régine P.M.
Netherlands, Rotterdam
Erasmus Mc
Zorn, Branko
Slovenia, Ljubljana
Univerzitetni Klinični Center Ljubljana
Polotsky, Alex Joel
United States, Aurora
University of Colorado Anschutz Medical Campus
La Vignera, Sandro
Italy, Catania
Università Degli Studi Di Catania
Eskenazi, Brenda
United States, Berkeley
Center for Environmental Research and Children's Health
Tremellen, Kelton P.
Australia, Adelaide
University of South Australia
Magnúsdóttir, Elín V.
Iceland, Reykjavik
Haskoli Islands
Fejes, Imre
Hungary, Szeged
Szegedi Tudományegyetem Szte
Hercberg, Serge
France, Bobigny
Équipe de Recherche en Épidémiologie Nutritionnelle Eren
France, Bobigny
Hopital Avicenne
Lévy, Rachel R.
France, Bondy
Hopital Jean-verdier
France, Bobigny
Équipe de Recherche en Épidémiologie Nutritionnelle Eren
Czernichow, Seb́astien
France, Versailles
Université de Versailles Saint-quentin-en-yvelines
France, Villejuif
Centre de Recherche en Épidémiologie et Santé Des Populations
Statistics
Citations: 528
Authors: 27
Affiliations: 26
Identifiers
Doi:
10.1093/humupd/dms050
ISSN:
13554786
e-ISSN:
14602369
Research Areas
Noncommunicable Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Case-Control Study
Study Approach
Systematic review
Participants Gender
Male