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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: Molecular docking study
European Journal of Medicinal Chemistry, Volume 45, No. 9, Year 2010
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Description
Novel derivatives of quinazoline (1-27) have been synthesized and tested for their antitumor activity against three tumor cell lines among these cell lines the human breast carcinoma cell line (MCF-7) in which EGFR is highly expressed. All tested compounds showed potent and selective activity against breast cancer (MCF-7) with IC50 range of 3.35-6.81 μg/ml. With regarding broad-spectrum activity compounds 5, 9, 15, 18 and 20 exploited potent antitumor against human liver cell line (HEPG2), human breast cell line (MCF-7) and human cervix cell line (HELA) with IC50 range of 3.35-5.59 μg/ml. Virtual screening was carried out through docking the designed compounds into the ATP binding site of epidermal growth factor receptor (EGFR) to predict if these compounds have analogous binding mode to the EGFR inhibitors. © 2010 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
El-Azab, Adel S.
Saudi Arabia, Riyadh
College of Pharmacy
Al-Omar, Mohamed Abdulrahman
Saudi Arabia, Riyadh
College of Pharmacy
Abdel-Aziz, Alaa A.M.
Saudi Arabia, Riyadh
College of Pharmacy
Abdel-Aziz, Naglaa I.
Egypt, Mansoura
Mansoura University
Elsayed, Magda A.A.
Egypt, Mansoura
Faculty of Pharmacy
Aleisa, Abdulaziz Mohamed A.
Saudi Arabia, Riyadh
College of Pharmacy
Sayed-Ahmed, Mohamed M.
Saudi Arabia, Riyadh
College of Pharmacy
Abdel-Hamide, Sami G.
Saudi Arabia, Al Kharj
Prince Sattam Bin Abdulaziz University
Statistics
Citations: 212
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1016/j.ejmech.2010.06.013
ISSN:
02235234
e-ISSN:
17683254
Research Areas
Cancer