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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemical engineering
A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins
Angewandte Chemie - International Edition, Volume 53, No. 38, Year 2014
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Description
A new class of small molecules, with an unprecedented trifluorothiazoline scaffold, were synthesized and their pro-apoptotic activity was evaluated. With an EC50 in the low micromolar range, these compounds proved to be potent inducers of apoptosis in a broad spectrum of tumor cell lines, regardless of the functional status of p53. Fast structure-activity relationship studies allowed the preparation of the strongest apoptosis-inducing candidate. Using a high performance affinity purification approach, we identified prohibitins 1 and 2, key proteins involved in the maintenance of cell viability, as the targets for these compounds. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Authors & Co-Authors
Preciado, Sara
Spain, Barcelona
Barcelona Science Park
Palmeri, Claudia Mariela
Spain, Barcelona
Universitat de Barcelona
Moncunill-Massaguer, Cristina
Spain, Barcelona
Universitat de Barcelona
Iglesias-Serret, Daniel
Spain, Barcelona
Universitat de Barcelona
González-Gironès, Diana M.
Spain, Barcelona
Universitat de Barcelona
Miguel, Miriam
Spain, Barcelona
Barcelona Science Park
Cosialls, Ana María
Spain, Barcelona
Universitat de Barcelona
Saura-Esteller, José
Spain, Barcelona
Universitat de Barcelona
Fabregat, Isabel
Spain, Barcelona
Universitat de Barcelona
Spain, Hospitalet de Llobregat
Institut D'investigació Biomedica de Bellvitge
Pons, Gabriel
Spain, Barcelona
Universitat de Barcelona
Alberício, Fernando
Spain, Barcelona
Universitat de Barcelona
Spain, Madrid
Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina
Gil, Joan
Spain, Barcelona
Universitat de Barcelona
Lavilla, Rodolfo
Spain, Barcelona
Barcelona Science Park
Spain, Barcelona
Universitat de Barcelona
Statistics
Citations: 36
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1002/anie.201405758
ISSN:
14337851
Research Areas
Cancer