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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis
Gut, Volume 68, No. 9, Year 2019
Notification
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Description
Objective: In this consensus statement, an international panel of experts deliver their opinions on key questions regarding the contribution of the human microbiome to carcinogenesis. Design: International experts in oncology and/or microbiome research were approached by personal communication to form a panel. A structured, iterative, methodology based around a 1-day roundtable discussion was employed to derive expert consensus on key questions in microbiome-oncology research. Results: Some 18 experts convened for the roundtable discussion and five key questions were identified regarding: (1) the relevance of dysbiosis/an altered gut microbiome to carcinogenesis; (2) potential mechanisms of microbiota-induced carcinogenesis; (3) conceptual frameworks describing how the human microbiome may drive carcinogenesis; (4) causation versus association; and (5) future directions for research in the field. The panel considered that, despite mechanistic and supporting evidence from animal and human studies, there is currently no direct evidence that the human commensal microbiome is a key determinant in the aetiopathogenesis of cancer. The panel cited the lack of large longitudinal, cohort studies as a principal deciding factor and agreed that this should be a future research priority. However, while acknowledging gaps in the evidence, expert opinion was that the microbiome, alongside environmental factors and an epigenetically/genetically vulnerable host, represents one apex of a tripartite, multidirectional interactome that drives carcinogenesis. Conclusion: Data from longitudinal cohort studies are needed to confirm the role of the human microbiome as a key driver in the aetiopathogenesis of cancer. © 2019 Author(s).
Authors & Co-Authors
Cunningham, David C.
United Kingdom, London
The Royal Marsden Hospital
Jobin, Christian
United States, Gainesville
University of Florida College of Medicine
Brown, Robert
United Kingdom, London
Imperial College London
O'Keefe, S. J.
United States, Pittsburgh
University of Pittsburgh
Gaskins, H. Rex
United States, Urbana
University of Illinois Urbana-champaign
Teare, Julian P.
United Kingdom, London
Imperial College London
Yu, Jun
Hong Kong, Hong Kong
Chinese University of Hong Kong
Hughes, David J.
Ireland, Dublin
University College Dublin
Verstraelen, Hans
Belgium, Ghent
Universitair Ziekenhuis Gent
Burton, Jeremy P.
Canada, London
Lawson Health Research Institute
O’Toole, Paul W. William
Ireland, Cork
University College Cork
Rosenberg, Daniel W.
United States, Farmington
Uconn School of Medicine
Marchesi, Julian Roberto
United Kingdom, London
Imperial College London
Kinross, James Mac Alister
United Kingdom, London
Imperial College London
Statistics
Citations: 147
Authors: 14
Affiliations: 12
Identifiers
Doi:
10.1136/gutjnl-2019-318556
ISSN:
00175749
Research Areas
Cancer
Study Design
Cohort Study