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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Positive immunostaining for platelet derived growth factor (PDGF) is an adverse prognostic factor in patients with advanced breast cancer
Breast Cancer Research and Treatment, Volume 32, No. 2, Year 1994
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Description
Previous studies suggest a prognostic role for PDGF in patients with breast cancer, with patients with high plasma PDGF levels or positive response to therapy. We have examined a further 58 patients with advanced breast cancer for the presence of tissue PDGF immunostaining. Patients displaying positive tissue immunostaining for PDGF had a highly significant shorter survival (p = 0.002) than patients with no immunostaining. In addition PDGF positive patients treated with combination chemotherapy had a significantly lower response rate (p = 0.05) than PDGF negative patients. These results confirm our previous findings that PDGF may be an important indicator of shortened survival and treatment failure in patients with advanced breast cancer. © 1994 Kluwer Academic Publishers.
Authors & Co-Authors
Seymour, Lesley K.
South Africa, Johannesburg
University of the Witwatersrand
Bezwoda, Werner Robert
South Africa, Johannesburg
University of the Witwatersrand
Statistics
Citations: 54
Authors: 2
Affiliations: 1
Identifiers
Doi:
10.1007/BF00665774
ISSN:
01676806
e-ISSN:
15737217
Research Areas
Cancer