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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Single-dose azithromycin prevents trichiasis recurrence following surgery: Randomized trial in Ethiopia
Archives of Ophthalmology, Volume 124, No. 3, Year 2006
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Description
Background: Trichiasis recurrence following surgery is a serious problem for trachoma programs. Objective: To determine if postoperative treatment with azithromycin compared with topical tetracycline reduces recurrence up to 1 year, and if azithromycin treatment of household members provides additional benefit compared with treating only the surgical patient. Design: A randomized, single-masked, clinical trial was conducted in Ethiopia. A total of 1452 patients with trichiasis were randomized 1:1:1 to the following 3 arms: single-dose (1 g) oral azithromycin alone, single-dose azithromycin for household members (20 mg/kg up to 1 g) plus the patient, or topical tetracycline (twice per day for 6 weeks). Main Outcome Measures: Trichiasis recurrence within 1 year following surgery. Results: The combined azithromycin groups had significantly fewer recurrences, 6.9 of 100 person-years overall, compared with topical tetracycline, 10.3 of 100 personyears (P=.047). There was no additional reduction in the arm that also treated household members, 8.1 of 100 person-years, compared with treating the surgical patients alone, 5.8 of 100 person-years (P=.19). Conclusions: In trachoma-endemic areas, a single dose ofazithromycinreducedpostoperative trichiasis recurrence rates by one third compared with topical tetracycline. Application to Clinical Practice: In countries where azithromycin is part of the Trachoma Control Program, patients with trachomatous trichiasis should be treated postoperatively to prevent recurrence. ©2006 American Medical Association. All rights reserved.
Authors & Co-Authors
Vos, Theo K.
United States, Baltimore
Wilmer Eye Institute
Gower, Emily W.
United States, Baltimore
Wilmer Eye Institute
Alemayehu, Wondu
Ethiopia, Addis Ababa
Orbis International, Addis Ababa
Melese, Muluken
Ethiopia, Addis Ababa
Orbis International, Addis Ababa
Muñoz, Beatriz E.
United States, Baltimore
Wilmer Eye Institute
Imeru, Alemush
United States, Baltimore
Wilmer Eye Institute
Worku, Alemayehu Gebeyehu
Ethiopia, Addis Ababa
Orbis International, Addis Ababa
Gaydos, Charlotte Ann
United States, Baltimore
Johns Hopkins University
Meinert, Curtis L.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Quinn, Thomas Charles
United States, Baltimore
Johns Hopkins University
Statistics
Citations: 87
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1001/archopht.124.3.309
Research Areas
Health System And Policy
Study Locations
Ethiopia