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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Sucralfate: The Bangkok review
Journal of Gastroenterology and Hepatology, Volume 9, No. 4, Year 1994
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Description
Abstract Sucralfate is a site‐protective ulcer healing drug with a remarkable range of mechanisms of action. Recent studies highlight the capacity of sucralfate to bind basic fibroblast growth factor (bFGF) and deliver it in high concentration to the ulcer. Basic fibroblast growth factor stimulates the production of granulation tissue, angiogenesis and re‐epithelization, thus improving the quality of ulcer healing. The effect of sucralfate in reducing parietal cell sensitivity may be another factor important in the lower relapse rate demonstrated after duodenal ulcer healing. Sucralfate has been demonstrated to be efficacious in healing both duodenal and gastric ulcers together with mild oesophagitis, and it is safe for both short‐term use and maintenance. In stress ulcer prophylaxis it is as effective as acid suppression or neutralization and has the advantage of lesser rates of nosocomial pneumonia than are demonstrated with antacids or H2 antagonists. The potential advantages of sucralfate lie in the better quality of ulcer healing associated with longer duration of remission. Copyright © 1994, Wiley Blackwell. All rights reserved
Authors & Co-Authors
Korman, Melvyn G.
Australia, Clayton
Monash Medical Centre
Bolin, Terry Dorcen
Australia, Sydney
Prince of Wales Hospital
Szabó, Sándor S.
United States, Boston
Brigham and Women's Hospital
Hunt, Richard H.
Canada, Hamilton
Mcmaster University
Marks, Israel N.Solly
South Africa, Observatory
Groote Schuur Hospital
Glise, Hans
Sweden, Trollhattan
Näl Hospital
Statistics
Citations: 17
Authors: 6
Affiliations: 6
Identifiers
Doi:
10.1111/j.1440-1746.1994.tb01264.x
ISSN:
08159319
e-ISSN:
14401746
Research Areas
Cancer