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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination
Nature Communications, Volume 14, No. 1, Article 6815, Year 2023
Notification
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Description
Respiratory mucosal immunity induced by vaccination is vital for protection from coronavirus infection in animal models. In humans, the capacity of peripheral vaccination to generate sustained immunity in the lung mucosa, and how this is influenced by prior SARS-CoV-2 infection, is unknown. Here we show using bronchoalveolar lavage samples that donors with history of both infection and vaccination have more airway mucosal SARS-CoV-2 antibodies and memory B cells than those only vaccinated. Infection also induces populations of airway spike-specific memory CD4+ and CD8+ T cells that are not expanded by vaccination alone. Airway mucosal T cells induced by infection have a distinct hierarchy of antigen specificity compared to the periphery. Spike-specific T cells persist in the lung mucosa for 7 months after the last immunising event. Thus, peripheral vaccination alone does not appear to induce durable lung mucosal immunity against SARS-CoV-2, supporting an argument for the need for vaccines targeting the airways. © 2023, The Author(s).
Authors & Co-Authors
Mitsi, Elena
United Kingdom, Oxford
University of Oxford
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Jesus, Reiné J
United Kingdom, Oxford
University of Oxford
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Collins, Andrea M.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Robinson, Ryan E.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Hyder-Wright, Angela D.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Farrar, Madlen C.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Liatsikos, Konstantinos
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Hamilton, Josh
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Urban, Britta Christina
United Kingdom, Oxford
University of Oxford
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Solórzano, Carla
United Kingdom, Oxford
University of Oxford
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Belij-Rammerstorfer, Sandra
United Kingdom, Oxford
University of Oxford
Lambe, Teresa
United Kingdom, Oxford
University of Oxford
Draper, Simon J.
United Kingdom, Oxford
University of Oxford
Weiskopf, Daniela
Unknown Affiliation
Maini, Mala K.
United Kingdom, London
University College London
Ferreira, Daniela Mulari
United Kingdom, Oxford
University of Oxford
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Statistics
Citations: 1
Authors: 16
Affiliations: 4
Identifiers
Doi:
10.1038/s41467-023-42433-w
ISSN:
20411723
Research Areas
Covid