Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Filaria-induced monocyte dysfunction and its reversal following treatment
Infection and Immunity, Volume 74, No. 8, Year 2006
Notification
URL copied to clipboard!
Description
Monocyte dysfunction in filarial infection has been proposed as one mechanism underlying the diminished antigen-specific T-cell response seen in patent lymphatic filariasis. Cytokine/chemokine production and gene expression in monocytes from filaria-infected patients and uninfected healthy donors were assessed unstimulated and in response to stimulation with Staphylococcus aureus Cowan I bacteria plus gamma interferon both before and 8 months following treatment. Monocytes from filaria-infected individuals were studded with intracellular microfilarial antigens. Furthermore, monocytes from these individuals were less capable of producing interleukin-8 (IL-8), Exodus II, MIP-1α, MIP-1β, and IL-1α and preferentially expressed genes involved in apoptosis and adhesion compared with monocytes from uninfected donors. Eight months following treatment with a single dose of ivermectin-albendazole, some of these defects were reversed, with monocyte production of IL-8, IL-1α, MIP-1α, and IL-10 being comparable to that seen in the uninfected controls. In addition, a marked increase in mRNA expression of genes associated with protein metabolism, particularly heat shock proteins, was seen compared with pretreatment expression. These data suggest that the function and gene expression of monocytes in filaria-infected patients are altered but that this dysfunction is partially reversible following antifilarial treatment. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC1539612/bin/iai_74_8_4409__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC1539612/bin/iai_74_8_4409__supplemental_table_1_and_2.zip
https://efashare.b-cdn.net/share/pmc/articles/PMC1539612/bin/iai_74_8_4409__Supplemental_figure_1_with_legend.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC1539612/bin/iai_74_8_4409__legends_for_supplemental_tables.doc
Authors & Co-Authors
Semnani, Roshanak Tolouei
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Keiser, Paul B.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Coulibaly, Youssouf
Mali, Bamako
University of Bamako
Keita, Falaye
Mali, Bamako
University of Bamako
Diallo, Abdallah Amadou
Mali, Bamako
University of Bamako
Traoré, Diakaridia
Mali, Bamako
University of Bamako
Diallo, Dapa Aly
Mali, Bamako
University of Bamako
Doumbo, Ogobara K.
Mali, Bamako
University of Bamako
Traoré, Sékou Fantamady
Mali, Bamako
University of Bamako
Kubofcik, Joseph
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Klion, Amy D.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Nutman, B. Thomas
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Statistics
Citations: 58
Authors: 12
Affiliations: 2
Identifiers
Doi:
10.1128/IAI.01106-05
ISSN:
00199567
Research Areas
Cancer
Genetics And Genomics