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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The interleukin-6 -147 G/C polymorphism is associated with increased risk of coronary artery disease in young South African Indian men
Metabolic Syndrome and Related Disorders, Volume 11, No. 3, Year 2013
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Description
Background: Interleukin-6 (IL-6) is a proinflammatory cytokine involved in the pathogenesis of chronic inflammatory diseases such as coronary artery disease (CAD). The -174 IL-6 G/C promoter polymorphism influences mRNA levels and protein expression and is implicated in CAD. The Indian population in South Africa, unlike the black community, has a high prevalence of premature CAD. This polymorphism has not been fully explored in this population. The present study assessed the -174 IL-6 G/C polymorphism in young Indian patients with angiographically documented CAD and compared them with age- and gender-matched Indian and black control subjects. Methods: Polymorphic variants were assessed by polymerase chain reaction-restriction fragment length polymorphism, and IL-6 levels were measured using enzyme-linked immunosorbent assay (ELISA). Results: The -174 IL-6 C allele was found with a higher frequency (23%) in the total Indian group compared to 2% in the black participants [P<0.0001, odds ratio (OR)=0.05, 95% confidence interval (CI) 0.018-0.14). The difference in frequency was more pronounced when Indian controls were compared to black controls (29% vs. 2%, respectively) (P<0.0001, OR=0.05, 95% CI 0.02-0.17). A significant association between the -174 IL-6 G allele and CAD was found in Indian patients compared to Indian controls (84% in cases vs. 71% in Indian controls; P=0.043, OR=0.47 95% CI 0.23-0.95). Levels of IL-6 in circulation were higher in black controls (6.62±0.63 pg/mL) compared to Indian controls (2.51±0.57 pg/mL) and CAD patients (1.46±0.36 pg/mL) (P<0.0001). Levels of IL-6 were higher in all groups with homozygous -174 IL-6 C alleles, but only significant in the healthy Indian control group (GG 3.73±0.94 pg/mL vs. GC/CC 0.89±0.5 pg/mL, P=0.0001). Conclusion: The presence of the IL-6 -174 G allele influences levels of IL-6 and increases the risk of CAD in South African Indians. © Copyright 2013, Mary Ann Liebert, Inc.
Authors & Co-Authors
Phulukdaree, Alisa
South Africa, Durban
The Nelson R. Mandela Medical School
Khan, Sajidah
South Africa, Durban
The Nelson R. Mandela Medical School
Ramkaran, Prithiksha
South Africa, Durban
The Nelson R. Mandela Medical School
Govender, Rishalan
South Africa, Durban
The Nelson R. Mandela Medical School
Moodley, Devapregasan
South Africa, Durban
The Nelson R. Mandela Medical School
Chuturgoon, Anil Amichund
South Africa, Durban
The Nelson R. Mandela Medical School
Statistics
Citations: 35
Authors: 6
Affiliations: 1
Identifiers
Doi:
10.1089/met.2012.0130
ISSN:
15404196
e-ISSN:
15578518
Research Areas
Genetics And Genomics
Maternal And Child Health
Study Design
Randomised Control Trial
Cross Sectional Study
Case-Control Study
Study Locations
South Africa
Participants Gender
Male