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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The changing patterns of bladder cancer in Egypt over the past 26 years
Cancer Causes and Control, Volume 19, No. 4, Year 2008
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Description
Objective: To evaluate temporal changes in histopathological types of bladder cancer and to assess associated changes in demographic, epidemiologic, and lifestyle risk factors. Methods: We abstracted data from all available medical records from the National Cancer Institute of Cairo University (NCI-Cairo). Six calendar years representing 5-year periods between 1980 and 2005 were evaluated. Information on demographics, schistosomal infection, clinical symptoms of bladder cancer, and tumor pathology was abstracted. Results: During this 26-year period, important changes in the frequency of histopathological types of bladder cancer occurred. We found a statistically significant association between time period of diagnosis and histopathological type. Patients diagnosed in 2005 had a sixfold higher odds associated with transitional cell carcinoma compared to those patients diagnosed in 1980 (odds ratio (OR) 6.00 (95% CI 4.00-8.97)). Conclusions: These data strongly suggest that the histopathological profile of bladder cancer in Egypt has changed significantly over the past 26 years. Historically, squamous cell carcinoma was the predominant form of bladder cancer in Egypt; however transitional cell carcinoma has become the most frequent type. These results corroborate findings from a few small-scale hospital-based studies which conclude that the etiology of bladder cancer in Egypt has changed significantly over the past 26 years. © 2008 Springer Science+Business Media B.V.
Authors & Co-Authors
Felix, Ashley S.
United States, Ann Arbor
University of Michigan, Ann Arbor
Soliman, Amr S.
United States, Ann Arbor
University of Michigan, Ann Arbor
Khaled, Hussein Mostafa
Egypt, Giza
Cairo University
Zaghloul, Mohamed S.
Egypt, Giza
Cairo University
Egypt
Minia Cancer Center
Banerjee, Mousumi M.
United States, Ann Arbor
University of Michigan, Ann Arbor
El-Baradie, Manal
Egypt, Giza
Cairo University
El-Kalawy, Mohamed
Egypt, Giza
Cairo University
Abd-Elsayed, Alaa A.
Egypt, Asyut
Faculty of Medicine
Ismail, Kadry
Egypt, Tanta
Gharbiah Population-based Cancer Registry
Hablas, Ahmed
Egypt, Tanta
Gharbiah Population-based Cancer Registry
Seifeldin, Ibrahim A.
Egypt, Tanta
Gharbiah Population-based Cancer Registry
Ramadan, Mohamed
Egypt, Tanta
Gharbiah Population-based Cancer Registry
Wilson, Mark Lee
United States, Ann Arbor
University of Michigan, Ann Arbor
Statistics
Citations: 157
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1007/s10552-007-9104-7
ISSN:
09575243
e-ISSN:
15737225
Research Areas
Cancer
Health System And Policy
Study Design
Case-Control Study
Study Locations
Egypt