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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Mycobacterium bovis infection at the interface between domestic and wild animals in Zambia
BMC Veterinary Research, Volume 8, Article 221, Year 2012
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Description
Background: In Zambia, the presence of bovine tuberculosis in both wild and domestic animals has long been acknowledged and mutual transmission between them has been predicted without any direct evidence. Elucidation of the circulating Mycobacterium bovis strains at wild and domestic animals interphase area in Zambia, where bovine tuberculosis was diagnosed in wildlife seemed to be important.Results: A PCR identified 15 and 37 M. bovis isolates from lechwe and cattle, respectively. Spoligotype analysis revealed that M. bovis strains from lechwe and cattle in Kafue basin clustered into a major node SB0120, where isolates outside the Kafue basin clustered into different nodes of SB0131 and SB0948. The comparatively higher variety of strains in cattle compared to lechwe elucidated by Mycobacterial Interspersed Repetitive Units-Variable Number Tandem Repeats analyses are consistent with cattle being the probable source of M. bovis in wild and domestic animals interphase area in Zambia.Conclusions: These results provide strong evidence of M. bovis strains transfer between cattle and lechwe, with the latter having developed into a sylvatic reservoir host. © 2012 Hang'ombe et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Hang'ombe, Mudenda Bernard
Zambia, Lusaka
University of Zambia
Munyeme, Musso
Zambia, Lusaka
University of Zambia
Nakajima, Chie
Japan, Sapporo
Hokkaido University
Fukushima, Yukari
Japan, Sapporo
Hokkaido University
Suzuki, Haruka
Japan, Sapporo
Hokkaido University
Matandiko, Wigganson
Zambia, Lusaka
Zambia Wildlife Authority
Ishii, Akihiro
Japan, Sapporo
Hokkaido University
Mweene, Aaron Simanyengwe
Zambia, Lusaka
University of Zambia
Suzuki, Yasuhiko
Japan, Sapporo
Hokkaido University
Japan, Tokyo
Japan International Cooperation Agency
Statistics
Citations: 30
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1186/1746-6148-8-221
e-ISSN:
17466148
Study Locations
Zambia