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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Growth in HIV-infected children receiving antiretroviral therapy at a pediatric infectious diseases clinic in Uganda
AIDS Patient Care and STDs, Volume 22, No. 3, Year 2008
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Description
Antiretroviral therapy (ART) improves growth and survival of HIV-infected individuals. We designed a retrospective cohort study to assess clinical factors associated with growth in HIV-infected children on ART in Uganda between July 2003 and March 2006. Height and weight measurements taken pre- and post-ART initiation for at least 6 months were age- and gender-standardized to CDC 2000 reference. We analyzed medical records of 749 children receiving ART. Descriptive and logistic regression analyses were conducted to identify covariates associated with risk of either stunting or being underweight. Longitudinal regression analysis with a mixed model using autoregressive covariance structure was used to compare change in height and weight before and after initiation of ART. The mean age of the study population at first visit was 7.5 years. Mean height-for-age, weight-for-age, and weight-for-height percentiles at first visit were 8.6, 7.7, and 7.9, respectively. At last visit mean height-for-age, weight-for-age, and weight-for-height percentiles were 8.6, 13.3, and 13.8, respectively. Baseline weight-for-age z score of 1 or more was protective against stunting (odds ratio [OR] 0.25, confidence interval [CI] 0.180.35) while baseline height-for-age z score of 1 or more was protective against becoming underweight (OR 0.75, CI 0.630.88). Children in World Health Organization (WHO) stages II, III, and IV at baseline were 1.5 times more likely to become underweight (OR 1.51, CI 1.072.14). Initiation of ART resulted in improvement in mean standardized weight-for-age z score and weight-for-age percentiles (p < 0.001). Weight-for-age percentile and z score improved significantly after initiation of ART. This pediatric population gained weight more rapidly than height after initiation of ART. © 2008 Mary Ann Liebert, Inc.
Authors & Co-Authors
Kabue, Mark M.
Malawi
Baylor College of Medicine
Malawi, Lilongwe
Kamuzu Central Hospital
Kekitiinwa, Adeodata R.
Uganda, Kampala
Baylor Coll of Med Children's Fdn-uganda
Maganda, Albert K.
Uganda, Kampala
Baylor Coll of Med Children's Fdn-uganda
Risser, Jan M.
United States, Houston
University of Texas School of Public Health
Chan, Wenyaw
United States, Houston
University of Texas School of Public Health
Kline, Mark W.
United States, Houston
Texas Children's Hospital
Statistics
Citations: 76
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1089/apc.2007.0049
ISSN:
10872914
Research Areas
Food Security
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Study Approach
Quantitative
Study Locations
Uganda