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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Brain aging in normal Egyptians: Cognition, education, personality, genetic and immunological study
Journal of the Neurological Sciences, Volume 211, No. 1-2, Year 2003
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Description
Studying the cognitive and immunological changes that occur in old age as well as genetic function have been considered an important subject to differentiate between normal brain aging and early dementia especially Alzheimer's disease. The aim of this study is to stress on age-related neuropsychological and electrophysiological (P300) changes in normal Egyptian subjects, to throw light on the value of genetic (Apo-E4 genotype) and immunological markers {interleukin-6 (IL-6) and intercellular adhesion molecules (ICAM-1) in the serum} as tools used in early detection of cognitive decline in cerebral aging. Ninety-four normal Egyptian subjects (below and above 60 years) were submitted to the following: (1) neuropsychological tests for testing memory, perception, psychomotor performance and attention, (2) Eysenck Personality Questionnaire (EPQ) for personality traits, (3) event-related potential study (P300, latency and amplitude), (4) genetic test for detection of Apolipoprotein E genotype and (5) immunological studies including detection of the level of IL-6 and ICAM-1 in serum. There was a significant impairment of memory, psychomotor performance and perception in elderly subjects particularly males and subjects with low level of education. Regarding personality, significantly high scores were obtained in neuroticism scale of EPQ in elderly subjects. Apo-E3/E3 was the most common genotype encountered in Egyptian subjects (49.1%). It was found that subjects with Apo-E4 genotype did significantly worse in scores of intentional memory test (sensory memory) when compared with other genotypes. Statistically significant impairment in attention and sensory memory was found in subjects with high IL-6 level. This could not be detected in subjects with high ICAM-1 level. In conclusion, advancing age and lower levels of education are considered risk factors for cognitive decline in normal brain aging. Neuropsychological tests remain as the highly sensitive tools for detection of early cognitive impairment. Neurotic traits are more encountered in old age. Apo-E4 genotype is associated with significant sensory (intentional) memory impairment. High IL-6 level in the serum is accompanied by significant impairment in attention and sensory (intentional) memory. © 2003 Elsevier Science B.V. All rights reserved.
Authors & Co-Authors
Elwan, Osamah H.
Egypt, Cairo
Faculty of Medicine
Madkour, Obsis
Egypt, Cairo
Faculty of Medicine
Elwan, Fadia Z.
Egypt, Giza
Cairo University
Mostafa, Mervat
Egypt, Cairo
Faculty of Medicine
Helmy, Azza Abbas
Egypt, Cairo
Faculty of Medicine
Abdal-Naseer, Maged
Egypt, Cairo
Faculty of Medicine
Shafy, Sanaa Abdel
Egypt, Giza
Cairo University
El Faiuomy, Nervana
Egypt, Cairo
Faculty of Medicine
Statistics
Citations: 35
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1016/S0022-510X(03)00032-7
ISSN:
0022510X
Research Areas
Genetics And Genomics
Mental Health