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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
Nature Communications, Volume 13, No. 1, Article 7251, Year 2022
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Description
Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention. © 2022, The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC9715550/bin/41467_2022_34312_MOESM1_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC9715550/bin/41467_2022_34312_MOESM2_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC9715550/bin/41467_2022_34312_MOESM3_ESM.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC9715550/bin/41467_2022_34312_MOESM4_ESM.zip
https://efashare.b-cdn.net/share/pmc/articles/PMC9715550/bin/41467_2022_34312_MOESM5_ESM.pdf
Authors & Co-Authors
Munk, Patrick
Denmark, Lyngby
Technical University of Denmark
Brinch, C.
Denmark, Lyngby
Technical University of Denmark
Møller, Frederik Duus
Denmark, Lyngby
Technical University of Denmark
Petersen, Thomas Nordahl
Denmark, Lyngby
Technical University of Denmark
Hendriksen, Rene Sjøgren
Denmark, Lyngby
Technical University of Denmark
Seyfarth, Anne Mette
Denmark, Lyngby
Technical University of Denmark
Kjeldgaard, Jette Sejer
Denmark, Lyngby
Technical University of Denmark
Svendsen, Christina Aaby
Denmark, Lyngby
Technical University of Denmark
van Bunnik, Bram A.D.
United Kingdom, Edinburgh
The University of Edinburgh
Berglund, Fanny
Sweden, Gothenburg
Göteborgs Universitet
Bego, Artan
Albania, Tirana
Institute of Public Health Albania
Power, Pablo
Argentina, Buenos Aires
Universidad de Buenos Aires
Rees, Catherine A.
Australia, Melbourne
Melbourne Water Corporation
Lambrinidis, Dionisia
Australia, Darwin
Charles Darwin University
Neilson, Elizabeth H.J.
Denmark, Copenhagen
Københavns Universitet
Gibb, Karen S.
Australia, Darwin
Charles Darwin University
Coventry, Kris
Australia, Melbourne
Melbourne Water Corporation
Collignon, Peter J.
Australia, Canberra
Canberra Hospital
Cassar, Susan
Unknown Affiliation
Allerberger, Franz J.
Austria, Vienna
Austrian Agency for Health and Food Safety
Begum, Anowara A.
Bangladesh, Dhaka
University of Dhaka
Hossain, Zenat Zebin
Bangladesh, Dhaka
University of Dhaka
Worrell, Carlon
Unknown Affiliation
Vandenberg, Olivier
Unknown Affiliation
Pieters, Ilse
Belgium, Aartselaar
Aquafin, Belgium
Victorien, Dougnon Tamègnon
Benin, Abomey-calavi
Polytechnic School of Abomey-calavi Epac
Gutierrez, Angela Daniela Salazar
Unknown Affiliation
Grujić, Vesna Rudić
Bosnia and Herzegovina, Banja Luka
University of Banja Luka
Mazalica, Nataša
Unknown Affiliation
Rahube, Teddie O.
Botswana, Palapye
Botswana International University of Science and Technology
Tagliati, Carlos A.
Brazil, Belo Horizonte
Universidade Federal de Minas Gerais
Rodrigues, Dália Dos Prazeres
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Oliveira, Guilherme Corrêa De
Brazil, Ouro Preto
Instituto Tecnológico Vale
Souza, Larissa Camila Ribeiro De
Brazil, Belo Horizonte
Universidade Federal de Minas Gerais
Ivanov, Ivan Nikolaev
Bulgaria, Sofia
National Center of Infectious and Parasitic Diseases Bulgaria
Juste, Bonkoungou Isidore
Burkina Faso, Ouagadougou
University of Ouagadougou
Oumar, Traoré
Burkina Faso, Ouagadougou
University of Ouagadougou
Sopheak, Thet
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Vuthy, Yith
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Ngandijo, Antoinette
Cameroon, Yaounde
Centre Pasteur du Cameroun
Nzouankeu, Ariane
Cameroon, Yaounde
Centre Pasteur du Cameroun
Olivier, Ziem A.Abah Jacques
Cameroon, Yaounde
Centre Pasteur du Cameroun
Yost, Christopher Karl
Canada, Regina
University of Regina
Kumar, Pratik
India, Jammu
Indian Institute of Technology Jammu
Brar, Satinder Kaur
Canada, Toronto
York University
Tabo, Djim Adjim
Chad, N'djamena
Universite de N'djamena
Adell, Aiko D.
Chile, Santiago
Universidad Andrés Bello
Paredes-Osses, Esteban
Chile, Santiago
Instituto de Salud Publica de Chile
Martínez, María Cristina
Chile, Santiago
Instituto de Salud Publica de Chile
Sara, Cuadros Orellana
Chile, Talca
Universidad Católica Del Maule
Ke, Changwen
China, Guangzhou
Guangdong Center for Disease Control and Prevention
Zheng, Huanying
China, Guangzhou
Guangdong Center for Disease Control and Prevention
Baisheng, Li
China, Guangzhou
Guangdong Center for Disease Control and Prevention
Lau, Lok Ting
Hong Kong, Hong Kong
The Hong Kong Polytechnic University
Chung, Teresa
Hong Kong, Hong Kong
The Hong Kong Polytechnic University
Jiao, Xiaoyang
China, Shantou
Shantou University Medical College
Yu, Yongjie
China, Nanjing
Nanjing University of Information Science & Technology
JiaYong, Zhao
China, Beijing
Chinese Center for Disease Control and Prevention
Morales, Johan F.Bernal
Unknown Affiliation
Valencia, María Fernanda Vásquez
Unknown Affiliation
Donado-Godoy, Pilar
Unknown Affiliation
Coulibaly, Kalpy Julien
Cote D'ivoire, Abidjan
Institut Pasteur de Cote-d'ivoire
Hrenović, Jasna J. J.
Croatia, Zagreb
University of Zagreb
Jergović, Matijana
Croatia, Zagreb
University of Zagreb School of Medicine
Karpíšková, Renáta
Czech Republic, Brno
Veterinary Research Institute, Brno
Deogratias, Zozo Nyarukweba
Democratic Republic Congo, Bukavu
Centre de Recherche en Sciences Naturelles Crsn
Elsborg, Bodil
Unknown Affiliation
Truelstrup-Hansen, Lisbeth
Denmark, Lyngby
Technical University of Denmark
Jensen, Pernille Erland
Denmark, Lyngby
Technical University of Denmark
Abouelnaga, M.
Egypt, Ismailia
Suez Canal University
Salem, Mohamed Fathy
Egypt, Sadat City
University of Sadat City
Koolmeister, Marliin
Unknown Affiliation
Legesse, Mengistu
Ethiopia, Addis Ababa
Addis Ababa University
Eguale, Tadesse
Ethiopia, Addis Ababa
Addis Ababa University
Heikinheimo, Annamari
Finland, Helsinki
Helsingin Yliopisto
Le Guyader, Soizick Françoise
France, Plouzane
Ifremer Institut Francais de Recherche Pour L'exploitation de la Mer
Schaeffer, Julien
France, Plouzane
Ifremer Institut Francais de Recherche Pour L'exploitation de la Mer
Villacis, Jose Eduardo
Unknown Affiliation
Sanneh, Bakary
Gambia, Kotu
Ministry of Health and Social Welfare
Malania, Lile
Georgia, Tbilisi
National Center for Disease Control and Public Health
Nitsche, Andreas
Germany, Berlin
Robert Koch Institute
Brinkmann, Annika
Germany, Berlin
Robert Koch Institute
Schubert, Sara
Germany, Dresden
Technische Universität Dresden
Hesse, Sina
Germany, Dresden
Technische Universität Dresden
Berendonk, Thomas Ulrich
Germany, Dresden
Technische Universität Dresden
Saba, Courage Kosi Setsoafia
Ghana, Tamale
University for Development Studies Ghana
Mohammed, Jibril
Ghana, Accra
University of Ghana
Feglo, Patrick Kwame
Ghana, Kumasi
Kwame Nkrumah University of Science & Technology
Banu, Regina Ama
Ghana, Accra
Csir - Water Research Institute Ghana
Kotzamanidis, Charalambos
Greece, Athens
Hellenic Agricultural Organization-dimitraada
Lytras, Efthymios S.
Unknown Affiliation
Lickes, Sergio A.
Guatemala, Guatemala City
Universidad de San Carlos de Guatemala
Kocsis, Béla
Hungary, Budapest
Semmelweis Egyetem
Solymosi, Norbert
Hungary, Budapest
University of Veterinary Medicine Budapest
Thorsteinsdottir, Thorunn Rafnar
Iceland, Reykjavik
Haskoli Islands
Mohamed Hatha, Abdulla
India, Kochi
Cochin University of Science and Technology
Ballal, Mamatha M.
India, Manipal
Kasturba Medical College, Manipal
Bangera, Sohan Rodney
Unknown Affiliation
Fani, Fereshteh
Iran, Shiraz
Shiraz University of Medical Sciences
Alebouyeh, Masoud
Iran, Tehran
Shahid Beheshti University of Medical Sciences
Morris, Dearbháile
Ireland, Galway
University of Galway
O’Connor, Louise
Ireland, Galway
University of Galway
Cormican, Martin G.M.
Ireland, Galway
University of Galway
Moran-Gilad, Jacob
Israel, Jerusalem
Ministry of Health
Battisti, Antonio
Italy, Rome
Istituto Zooprofilattico Sperimentale Delle Regioni Lazio e Toscana
Corno, Gianluca
Italy, Monterotondo
Istituto Di Ricerca Sulle Acque, Italy
Di Cesare, Andrea D.
Italy, Monterotondo
Istituto Di Ricerca Sulle Acque, Italy
Alba, Patricia
Italy, Rome
Istituto Zooprofilattico Sperimentale Delle Regioni Lazio e Toscana
Hisatsune, Junzo
Japan, Tokyo
National Institute of Infectious Diseases
Yu, Liansheng
Japan, Tokyo
National Institute of Infectious Diseases
Kuroda, Makoto
Japan, Tokyo
National Institute of Infectious Diseases
Sugai, Motoyuki
Japan, Tokyo
National Institute of Infectious Diseases
Kayama, Shizuo
Japan, Tokyo
National Institute of Infectious Diseases
Shakenova, Zeinegul
Unknown Affiliation
Kiiyukia, Ciira
Kenya, Thika
Mount Kenya University
Ng’eno, Eric
Kenya, Nairobi
Kenya Medical Research Institute
Raka, Lul
Serbia, Pristina
National Institute of Public Health of Kosovo
Jamil, Kazi M.A.
Kuwait, Shuwaikh
Kuwait Institute for Scientific Research
Fakhraldeen, Saja Adel
Kuwait, Shuwaikh
Kuwait Institute for Scientific Research
Berzins, Aivars
Latvia, Riga
Institute of Food Safety, Animal Health and Environment - Bior
Avsejenko, Jelena
Latvia, Riga
Institute of Food Safety, Animal Health and Environment - Bior
Bartkevics, Vadims
Latvia, Riga
Institute of Food Safety, Animal Health and Environment - Bior
Matar, Ghassan
Lebanon, Beirut
American University of Beirut
Daoud, Ziad D.
United States, Mount Pleasant
Central Michigan University
Penny, Christian
Luxembourg, Esch-sur-alzette
Luxembourg Institute of Science and Technology
Bastaraud, Alexandra
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Collard, Jean Marc
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Samison, Luc Hervé
Madagascar, Antananarivo
Université D'antananarivo
Rakoto-Andrianarivelo, Mala
Madagascar, Antananarivo
Université D'antananarivo
Banda, Daniel Lawadi
Malawi, Zomba
University of Malawi
Heera, Rajandas
Unknown Affiliation
Parimannan, Sivachandran
Unknown Affiliation
Haber, Malcolm Vella
Unknown Affiliation
Santchurn, Sunita Jeewantee
Mauritius, Reduit
University of Mauritius
Bouchrif, Brahim
Morocco, Casablanca
Institut Pasteur du Maroc
Karraouan, Bouchra
Morocco, Casablanca
Institut Pasteur du Maroc
Vubil, Delfino Carlos
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Pal, Pushkar
Unknown Affiliation
Schmitt, Heike
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
van Passel, Mark W.J.
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Jeunen, Gert Jan
New Zealand, Dunedin
University of Otago
Gemmell, Neil J.
New Zealand, Dunedin
University of Otago
Chambers, S. T.
New Zealand, Christchurch
University of Otago, Christchurch
Vílchez, Samuel
Unknown Affiliation
Ahmed, Akeem Olayiwola
Nigeria, Ilorin
University of Ilorin
Odetokun, Ismail
Nigeria, Ilorin
University of Ilorin
Fashae, Kayode F.
Nigeria, Ibadan
University of Ibadan
Wester, Astrid Louise
Norway, Oslo
Folkehelseinstituttet
Holmstad, Rune
Unknown Affiliation
Mohsin, Mashkoor
Pakistan, Faisalabad
University of Agriculture, Faisalabad
Hasan, Rumina S.
Pakistan, Karachi
The Aga Khan University
Shakoor’, Sadia
Pakistan, Karachi
The Aga Khan University
Gustafson, Natalie Weiler
Paraguay, Asuncion
Laboratorio Central de Salud Pública
Rojas, Maria Luz Zamudio
Peru, Lima
Instituto Nacional de Salud, Lima
Wasyl, Dariusz
Poland, Pulawy
Państwowy Instytut Weterynaryjny - Państwowy Instytut Badawczy
Manaia, Célia Manaia
Portugal, Porto
Escola Superior de Biotecnologia da Universidade Católica Portuguesa
Bosevska, Golubinka
North Macedonia, Skopje
Institute of Public Health of the Republic of North Macedonia
Kochubovski, Mihail V.
North Macedonia, Skopje
Institute of Public Health of the Republic of North Macedonia
Hong, Pei-Ying
Saudi Arabia, Thuwal
King Abdullah University of Science and Technology
Gassama, Amy
Senegal, Dakar
Institut Pasteur de Dakar
Radosavljević, Vladimir I.
Serbia, Belgrade
University of Belgrade Faculty of Veterinary Medicine
Tay, Moon Yue Feng
Singapore, Singapore City
Nanyang Technological University
Zuniga-Montanez, Rogelio E.
Singapore, Singapore City
Nanyang Technological University
Wuertz, Stefan
Singapore, Singapore City
Nanyang Technological University
Gavačová, Dagmar
Slovakia, Bratislava
Public Health Authority of the Slovak Republic
Pastuchová, Katarína
Slovakia, Bratislava
Public Health Authority of the Slovak Republic
Truska, Peter
Slovakia, Bratislava
Public Health Authority of the Slovak Republic
Trkov, Marija
Unknown Affiliation
Keddy, Karen Helena
South Africa, Johannesburg
Independent Consultant
Esterhuyse, Kerneels
South Africa, Pretoria
Daspoort Waste Water Treatment Works
Quintela-Baluja, Marcos
Unknown Affiliation
Cerdà-Cuèllar, Marta
Spain, Cerdanyola Del Valles
Centre Recerca en Sanitat Animal
Pathirage, Sujatha
Unknown Affiliation
Norrgren, Leif
Sweden, Uppsala
Sveriges Lantbruksuniversitet
Örn, Stefan
Sweden, Uppsala
Sveriges Lantbruksuniversitet
van der Heijden, Tanja
Unknown Affiliation
Kumburu, Happiness Houka
Tanzania, Moshi
Kilimanjaro Clinical Research Institute
Mdegela, Robinson Hammerthon
Tanzania, Morogoro
Sokoine University of Agriculture
Hounmanou, Yaovi Mahuton Gildas
Denmark, Copenhagen
Københavns Universitet
Thamlikitkul, Visanu
Thailand, Bangkok
Faculty of Medicine Siriraj Hospital, Mahidol University
de Roda-Husman, Ana Maria
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Bidjada, Bawimodom
Togo, Lomι
National Institute of Hygiene
Njanpop-Lafourcade, Berthe Marie
Unknown Affiliation
Nikiema-Pessinaba, Somtinda Christelle
Unknown Affiliation
Levent, Belkıs
Unknown Affiliation
Kürekci, Cemil
Turkey, Antakya
Mustafa Kemal Üniversitesi
Ejobi, Francis
Uganda, Kampala
Makerere University
Kalule, John Bosco
Uganda, Kampala
Makerere University
Thomsen, Jens
Unknown Affiliation
Leonard, Anne F.C.
United Kingdom, Exeter
University of Exeter Medical School
Graham, David W.
United Kingdom, Newcastle
Newcastle University
Bunce, Joshua T.
United Kingdom, Newcastle
Newcastle University
Zhang, Lihong
United Kingdom, Exeter
University of Exeter Medical School
Gaze, William Hugo
United Kingdom, Exeter
University of Exeter Medical School
Capone, Drew
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Sozzi, Emanuele
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Brown, Joe M.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Meschke, John Scott
United States, Seattle
University of Washington
Sobsey, Mark D.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Beck, Nicola Koren
United States, Seattle
University of Washington
Wittum, Thomas E.
United States, Columbus
The Ohio State University
Kwenda, Geoffrey
Zambia, Lusaka
University of Zambia
Larsson, D. G.Joakim
Sweden, Gothenburg
Göteborgs Universitet
Koopmans, Marion P.G.
Netherlands, Rotterdam
Erasmus Mc
Woolhouse, Mark E.J.
United Kingdom, Edinburgh
The University of Edinburgh
Aarestrup, Frank Møller
Denmark, Lyngby
Technical University of Denmark
Statistics
Citations: 62
Authors: 206
Affiliations: 132
Identifiers
Doi:
10.1038/s41467-022-34312-7
ISSN:
20411723
Research Areas
Genetics And Genomics