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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Additional burden of asymptomatic and sub-patent malaria infections during low transmission season in forested tribal villages in Chhattisgarh, India
Malaria Journal, Volume 16, No. 1, Article 320, Year 2017
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Description
Background: The burden of sub-patent malaria is difficult to recognize in low endemic areas due to limitation of diagnostic tools, and techniques. Polymerase chain reaction (PCR), a molecular based technique, is one of the key methods for detection of low parasite density infections. The study objective was to assess the additional burden of asymptomatic and sub-patent malaria infection among tribal populations inhabiting three endemic villages in Keshkal sub-district, Chhattisgarh, India. A cross-sectional survey was conducted in March-June 2016, during the low transmission season, to measure and compare prevalence of malaria infection using three diagnostics: rapid diagnostic test, microscopy and nested-PCR. Results: Out of 437 individuals enrolled in the study, 103 (23.6%) were malaria positive by PCR and/or microscopy of whom 89.3% were Plasmodium falciparum cases, 77.7% were afebrile and 35.9% had sub-patent infections. Conclusions: A substantial number of asymptomatic and sub-patent malaria infections were identified in the survey. Hence, strategies for identifying and reducing the hidden burden of asymptomatic and sub-patent infections should focus on forest rural tribal areas using more sensitive molecular diagnostic methods to curtail malaria transmission. © 2017 The Author(s).
Authors & Co-Authors
Chourasia, Mehul Kumar
India, New Delhi
National Institute of Malaria Research India
Kamaraju, Raghavendra
India, New Delhi
National Institute of Malaria Research India
Bhatt, Rajendra Mohan
India, New Delhi
National Institute of Malaria Research India
Swain, Dipak Kumar
India, New Delhi
National Institute of Malaria Research India
Kleinschmidt, Immo
United Kingdom, London
London School of Hygiene & Tropical Medicine
Statistics
Citations: 17
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1186/s12936-017-1968-8
ISSN:
14752875
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative