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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Group A rotavirus strains circulating in the eastern center of Tunisia during a ten-year period (1995-2004)
Journal of Medical Virology, Volume 79, No. 7, Year 2007
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Description
An epidemiological survey investigating rotavirus infections in children was undertaken in the Eastern Center of Tunisia between January 1995 and December 2004. A total of 982 faecal specimens collected from children less than 5 years in age were screened by enzyme-linked immunosorbent assay (ELISA) or latex agglutination assay for the presence of group A rotavirus antigen. Rotavirus-positive samples were used for G and P typing by multiplex semi-nested reverse transcription-PCR. Rotaviruses were detected in 22% (n = 220) of stools. Of these, 164 were typed for VP7: G genotypes found were G1 (59%), G2 (2%), G3 (9%), G4 (10%), G8 (1%), and G9 (1%). Sixteen specimens (9%) showed mixed G profiles. A total of 119 specimens were typed for VP4. P genotypes detected were P[8] (32%), P[6] (15%), and P[4] (13%). Mixed P profiles were also detected (6%). Although the distribution of the detected genotypes appeared to change annually, G1P[8] rotavirus strains always predominated during the 10-year period of study. This is the first report of rotaviruses in Tunisia with unconventional VP7 serotypes such as G8 and G9, highlighting the need for continual surveillance of emerging strains in Northern Africa. Indeed, the new commercial vaccines only contain the VP7 genes that dictate G1 or G1 to G4 specificities. These vaccines may protect less well against unusual strains circulating in countries planning to implement a rotavirus vaccine strategy. © 2007 Wiley-Liss, Inc.
Authors & Co-Authors
Chouikha, Anissa
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Fodha, Imène
Tunisia, Sousse
Chu Sahloul
Noomen, S.
Tunisia, Monastir
Chu Fattouma-bourguiba
Bouzid, L.
Tunisia, Sfax
Chu Hedi-chaker
Mastouri, Maha
Tunisia, Monastir
Chu Fattouma-bourguiba
Peenze, Ina
South Africa, Sovenga
University of Limpopo
de Beer, Mariet C.
South Africa, Sovenga
University of Limpopo
Dewar, John Barr
South Africa, Sovenga
University of Limpopo
Geyer, Annelise
South Africa, Sovenga
University of Limpopo
Sfar, Mohammed Tahar
Tunisia, Mahdia
Hôpital Tahar Sfar
Gueddiche, Néji M.
Tunisia, Monastir
Chu Fattouma-bourguiba
Messaadi, Feriel
Tunisia, Sfax
Chu Hedi-chaker
Trabelsi, Abdelhalim
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Tunisia, Sousse
Chu Sahloul
Boujâafar, Noureddine
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Steele, Andrew Duncan
Switzerland, Geneva
Organisation Mondiale de la Santé
Statistics
Citations: 43
Authors: 15
Affiliations: 7
Identifiers
Doi:
10.1002/jmv.20919
ISSN:
01466615
e-ISSN:
10969071
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Tunisia