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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Relationship between kdr mutation and resistance to pyrethroid and DDT insecticides in natural populations of Anopheles gambiae
Journal of Medical Entomology, Volume 45, No. 2, Year 2008
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Description
The spread of insecticide resistance genes in Anopheles gambiae Giles sensu stricto threatens to compromise vector-based malaria control programs. Two mutations at the same locus in the voltage-gated sodium channel gene are known to confer knockdown resistance (kdr) to pyrethroids and DDT. Kdr-e involves a leucine-serine substitution, and it was until recently thought to be restricted to East Africa, whereas kdr-w, which involves a leucine-phenylalanine substitution, is associated with resistance in West Africa. In this study, we analyze the frequency and relationship between the kdr genotypes and resistance to type I and type II pyrethroids and DDT by using WHO test kits in both the Forest-M and S molecular forms of An. gambiae in Cameroon. Both kdr-w and kdr-e polymorphisms were found in sympatric An. gambiae, and in many cases in the same mosquito. Kdr-e and kdr-w were detected in both forms, but they were predominant in the S form. Both kdr-e and kdr-w were closely associated with resistance to DDT and weakly associated with resistance to type II pyrethroids. Kdr-w conferred greater resistance to permethrin than kdr-e. We also describe a modified diagnostic designed to detect both resistant alleles simultaneously. © 2008 Entomological Society of America.
Authors & Co-Authors
Reimer, Lisa J.
United States, Davis
University of California, Davis
Fondjo, Etienne
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Patchoké, Salomon
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Diallo, Bréhima
United States, Davis
University of California, Davis
Lee, Yoosook
United States, Davis
University of California, Davis
Ng, Arash
United States, Davis
University of California, Davis
Ndjemai, Hamadou
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Atangana, Jean
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Traoré, Sékou Fantamady
United States, Davis
University of California, Davis
Lanzaro, Gregory C.
Cameroon, Yaounde
Ministry of Health
Cornel, Anthony John
United States, Davis
University of California, Davis
Statistics
Citations: 128
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.1603/0022-2585(2008)45[260:RBKMAR]2.0.CO;2
ISSN:
00222585
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Locations
Multi-countries
Cameroon