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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
engineering
A laboratory model to quantitate the resistance of collagen vascular grafts to biodegradation
Journal of Biomedical Materials Research, Volume 25, No. 3, Year 1991
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Description
Recent reports have shown that despite extensive preclinical testing, vascular grafts of biological origin undergo severe biodegradation and aneurysm formation after two or more years of implantation in man. The purpose of this study was to develop a laboratory model to quantitate and correlate the stability of crosslinked collagen grafts in vitro and in vivo. This resistance to biodegradation was assessed by measuring changes in suture pullout force and sample weight in response to controlled digestion with bacterial collagenase, in 0.5‐cm‐long cylindrical graft segments (chemically processed bovine carotid artery and human umbilical cord vein) that were implanted in the rat subcutis for 2 to 12 weeks. Scar tissue was removed from the explants by brief enzymatic digestion, a process that was inhibited when graft segments had become infected. Changes in dry weight were more consistent than were changes in wet weight; drying the graft segments had no effect on their degradation in vivo or in vitro. Intact cylindrical rings suffered somewhat less damage than did opened, flattened cylinders. Graft degradation increased markedly with implantation time, and was detected after only 3 weeks. We conclude that the rat subcutis model, when combined with controlled enzymatic digestion, first to remove scar tissue and then to challenge structural integrity, provides an accelerated assay by which to predict the stability of collagen vascular grafts. Copyright © 1991 John Wiley & Sons, Inc.
Authors & Co-Authors
Megerman, Joseph
United States, Boston
Massachusetts General Hospital
Reddy, E.
South Africa, Congella
University of Natal, Faculty of Medicine
L'Italien, Gilbert J.
United States, Boston
Massachusetts General Hospital
Warnock, David F.
United States, Boston
Massachusetts General Hospital
Abbott, William M.
United States, Boston
Massachusetts General Hospital
Statistics
Citations: 7
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1002/jbm.820250303
ISSN:
00219304
e-ISSN:
10974636