Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Nonspecific effect of BCG vaccination at birth on early childhood infections: A randomized, clinical multicenter trial
Pediatric Research, Volume 80, No. 5, Year 2016
Notification
URL copied to clipboard!
Description
Background: Childhood infections are common and Bacillus Calmette-Guérin (BCG) vaccination at birth may prevent these via nonspecific effects. Methods: A randomized, clinical multicenter trial. All women planning to give birth (n = 16,521) at the three study sites were invited during the recruitment period. Participating children were randomized to receive BCG within 7 d of birth or to a no intervention control group. Parent-reported infections (events) were collected using telephone interviews at 3 and 13 mo. Data collectors were blinded to allocation. Results: The analyses included 4,224/4,262 (99%) and 4,192/4,262 (98%) children at 3 and 13 mo. From 0 to 3 mo, there were 291 events in the BCG group vs. 336 events in the control group, incidence rate ratio (IRR) = 0.87 (95% confidence interval (CI): 0.72 to 1.05). In this age group, the IRR was 0.62 (95% CI: 0.39 to 0.98) if the mother was BCG vaccinated. From 3 to 13 mo, there were 7,028 vs. 6,791 events, IRR = 1.02 (95% CI: 0.97 to 1.07). Conclusion: This study did not find a nonspecific public health benefit of BCG on parent-reported infections. BCG may have reduced the incidence of infections in children of BCG-vaccinated mothers during the first 3 mo. © 2016 International Pediatric Research Foundation, Inc.
Authors & Co-Authors
Kjaergaard, Jesper
Denmark, Copenhagen
Copenhagen University Hospital
Birk, Nina Marie
Denmark, Copenhagen
Copenhagen University Hospital
Nissen, Thomas Nørrelykke
Denmark, Copenhagen
Copenhagen University Hospital
Benn, Christine Stabell
Denmark, Copenhagen
Statens Serum Institut
Jeppesen, Dorthe Lisbeth
Denmark, Copenhagen
Copenhagen University Hospital
Pryds, Ole Axel
Denmark, Copenhagen
Copenhagen University Hospital
Kofoed, Poul Erik Lund
Denmark, Kolding
Sygehus Lillebælt - Kolding
Aaby, Peter
Denmark, Copenhagen
Statens Serum Institut
Greisen, Gorm
Denmark, Copenhagen
Copenhagen University Hospital
Stensballe, Lone Graff
Denmark, Copenhagen
Copenhagen University Hospital
Statistics
Citations: 38
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1038/pr.2016.142
ISSN:
00313998
Research Areas
Maternal And Child Health
Study Design
Randomised Control Trial
Cohort Study
Participants Gender
Female