Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
High population frequencies of apol1 risk variants are associated with increased prevalence of non-diabetic chronic kidney disease in the igbo people from south-eastern nigeria
Nephron - Clinical Practice, Volume 123, No. 1-2, Year 2013
Notification
URL copied to clipboard!
Description
Background: Continental Africa is facing an epidemic of chronic kidney disease (CKD). APOL1 risk variants have been shown to be strongly associated with an increased risk for non-diabetic kidney disease including HIV nephropathy, primary non-monogenic focal and segmental glomerulosclerosis, and hypertension-attributed nephropathy among African ancestry populations in the USA. The world's highest frequencies of APOL1 risk alleles have been reported in West African nations, overlapping regions with a high incidence of CKD and hypertension. One such region is south-eastern Nigeria, and therefore we sought to quantify the association of APOL1 risk alleles with CKD in this region. Methods: APOL1 risk variants were genotyped in a case-control sample set consisting of non-diabetic, CKD patients (n = 44) and control individuals (n = 43) from Enugu and Abakaliki, Nigeria. Results: We found a high frequency of two APOL1 risk alleles in the general population of Igbo people of south-eastern Nigeria (23.3%). The two APOL1 risk allele frequency in the CKD patient group was 66%. Logistic regression analysis under a recessive inheritance model showed a strong and significant association of APOL1 two-risk alleles with CKD, yielding an odds ratio of 6.4 (unadjusted p = 1.2E-4); following correction for age, gender, HIV and BMI, the odds ratio was 4.8 (adjusted p = 5.1E-03). Conclusion: APOL1 risk variants are common in the Igbo population of south-eastern Nigeria, and are also highly associated with non-diabetic CKD in this area. APOL1 may explain the increased prevalence of CKD in this region. Copyright © 2013 S. Karger AG, Basel.
Authors & Co-Authors
Ulasi, Ifeoma I.
Nigeria, Abakaliki
Federal Teaching Hospital
Tzur, Shay
Israel, Haifa
Technion - Israel Institute of Technology
Wasser, Walter G.
Israel, Haifa
Molecular Medicine Laboratory
Shemer, Revital
Israel, Haifa
Technion - Israel Institute of Technology
Kruzel-Davila, Etty D.
Unknown Affiliation
Ijoma, Chinwuba K.
Unknown Affiliation
Onodugo, Obinna Donatus
Unknown Affiliation
Okoye, Julius U.
Unknown Affiliation
Arodiwe, Ejikeme Benneth
Unknown Affiliation
Ifebunandu, Ngozi Appolonia
Nigeria, Abakaliki
Federal Teaching Hospital
Chukwuka, Chinwe Judith
Unknown Affiliation
Onyedum, Cajetan Chigozie
Unknown Affiliation
Ijoma, Uchenna Nkemdilim
Unknown Affiliation
Nna, Emmanuel Okechukwu
Nigeria, Naukka
University of Nigeria
Onuigbo, Macaulay Amechi Chukwukadibia
United States, Rochester
Mayo Clinic
Rosset, Saharon
Israel, Tel Aviv-yafo
Tel Aviv University
Skorecki, Karl L.
Israel, Haifa
Technion - Israel Institute of Technology
Israel, Haifa
Molecular Medicine Laboratory
Statistics
Citations: 73
Authors: 17
Affiliations: 6
Identifiers
Doi:
10.1159000353223
ISSN:
16602110
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Study Approach
Quantitative
Study Locations
Nigeria