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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The origins and future of sentinel: An early-warning system for pandemic preemption and response
Viruses, Volume 13, No. 8, Article 1605, Year 2021
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Description
While investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in Lassa virus binding and entry. This led us to pursue field work to test our hypothesis that natural selection acting on LARGE—detected in the Yoruba population of Nigeria—conferred resistance to Lassa Fever in some West African populations. As we delved further, we conjectured that the “emerging” nature of recently discovered diseases like Lassa fever is related to a newfound capacity for detection, rather than a novel viral presence, and that humans have in fact been exposed to the viruses that cause such diseases for much longer than previously suspected. Dr. Stefan Kunz’s critical efforts not only laid the groundwork for this discovery, but also inspired and catalyzed a series of events that birthed Sentinel, an ambitious and large-scale pandemic prevention effort in West Africa. Sentinel aims to detect and characterize deadly pathogens before they spread across the globe, through implementation of its three fundamental pillars: Detect, Connect, and Empower. More specifically, Sentinel is designed to detect known and novel infections rapidly, connect and share information in real time to identify emerging threats, and empower the public health community to improve pandemic preparedness and response anywhere in the world. We are proud to dedicate this work to Stefan Kunz, and eagerly invite new collaborators, experts, and others to join us in our efforts. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Authors & Co-Authors
Botti-Lodovico, Yolanda
United States, Cambridge
Broad Institute
Nair, Parvathy
United States, Chevy Chase
Howard Hughes Medical Institute
Nosamiefan, Dolo
Nigeria, Ede
Redeemer‘s University
Stremlau, Matthew H.
United States, Washington
Change the Equation Inc
Schaffner, Stephen F.
United States, Cambridge
Broad Institute
United States, Cambridge
Harvard University
Agignoae, Sebastian V.
United States, Cambridge
Broad Institute
United States, Cambridge
John F. Kennedy School of Government
Aiyepada, John Oke
Nigeria, Irrua, Edo State
Irrua Specialist Teaching Hospital
Ajogbasile, Fehintola V.
Nigeria, Ede
Redeemer‘s University
Akpede, George Obozokhale
Nigeria, Irrua, Edo State
Irrua Specialist Teaching Hospital
Nigeria, Ekpoma
Ambrose Alli University
Alhasan, Foday
Sierra Leone, Kenema
Kenema Government Hospital
Andersen, Kristian G.
United States, San Diego
Scripps Research Institute
United States, La Jolla
Scripps Translational Science Institute
Asogun, Danny A.
Nigeria, Ekpoma
Ambrose Alli University
Ayodeji, Olufemi Oluwafemi
Nigeria
Federal Medical Centre Nigeria
Badiane, Aïda Sadikh
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Barnes, Kayla G.
United States, Cambridge
Broad Institute
United States, Cambridge
Harvard University
Bauer, Matthew R.
United States, Boston
Harvard Medical School
Bell-Kareem, Antoinette R.
United States, New Orleans
Tulane Medical Center
Benard, Muoebonam Ekene
Nigeria, Irrua, Edo State
Irrua Specialist Teaching Hospital
Benevolence, Ebo Ohomoime
Nigeria, Irrua, Edo State
Irrua Specialist Teaching Hospital
Blessing, Osiemi
Nigeria, Irrua, Edo State
Irrua Specialist Teaching Hospital
Boehm, Chloe K.
United States, Cambridge
Broad Institute
United States, Princeton
Princeton University
Boisen, Matt L.
United States, Germantown
Zalgen Labs
Bond, Nell G.
United States, New Orleans
Tulane Medical Center
Branco, Luis M.
United States, Germantown
Zalgen Labs
Butts, Michael J.
United States, Cambridge
Broad Institute
United States, Cambridge
Harvard University
Carter, Amber
United States, Cambridge
Broad Institute
Colubri, Andrés
United States, Cambridge
Broad Institute
United States, Worcester
University of Massachusetts Chan Medical School
Déme, Awa Bineta
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
DeRuff, Katherine C.
United States, Cambridge
Broad Institute
Diédhiou, Younouss M.
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Edamhande, Akhilomen Patience
Nigeria, Irrua, Edo State
Irrua Specialist Teaching Hospital
Elhamoumi, Siham
United States, Cambridge
Broad Institute
Engel, Emily J.
United States, New Orleans
Tulane Medical Center
Eromon, Philomena E.
Nigeria, Ede
Redeemer‘s University
Fallah, Mosoka Papa
Liberia, Bassa Town, Lower Johnsonville
Refuge Place International
Folarin, Onikepe Abiola
Nigeria, Ede
Redeemer‘s University
Fry, Ben
United States, Boston
Fathom Information Design
Garry, Robert F.
United States, New Orleans
Tulane Medical Center
Gaye, Amy
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Gbakie, Michael A.
Sierra Leone, Kenema
Kenema Government Hospital
Gevao, Sahr M.
Sierra Leone, Freetown
University of Sierra Leone
Gionet, Gabrielle L.
United States, Cambridge
Broad Institute
Gladden-Young, Adrianne
United States, Cambridge
Broad Institute
Goba, Augustine
Sierra Leone, Freetown
University of Sierra Leone
Gomis, Jules François
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Happi, Anise N.
Nigeria, Ede
Redeemer‘s University
Houghton, Mary
United States, Cambridge
Broad Institute
Ihekweazu, Chikwe A.
Nigeria, Irrua, Edo State
Irrua Specialist Teaching Hospital
Iruolagbe, Christopher Ojemiega
Nigeria, Irrua, Edo State
Irrua Specialist Teaching Hospital
Jackson, Jonathan L.
United States, Cambridge
Dimagi, Inc.
Jalloh, Simbirie C.
Sierra Leone, Freetown
University of Sierra Leone
Johnson, Jeremy K.
United States, Cambridge
Broad Institute
Kanneh, Lansana D.
Sierra Leone, Kenema
Kenema Government Hospital
Kayode, Tolulope
Nigeria, Ede
Redeemer‘s University
Kemball, Molly E.
United States, Cambridge
Broad Institute
United States, Cambridge
Harvard University
Ojide, Chiedozie Kingsley
Nigeria, Abakaliki, Ebonyi
Alex Ekwueme Federal University Teaching Hospital Abakaliki
Koroma, Veronica J.
Sierra Leone, Kenema
Kenema Government Hospital
Kotliar, Dylan
United States, Cambridge
Broad Institute
United States, Cambridge
Harvard University
Mehta, Samar B.
United States, Baltimore
University of Maryland Medical Center
Metsky, Hayden C.
United States, Cambridge
Broad Institute
Michael, Airende
Nigeria, Irrua, Edo State
Irrua Specialist Teaching Hospital
Mirhashemi, Marzieh Ezzaty
United States, Cambridge
Broad Institute
Modjarrad, Kayvon
United States, Silver Spring
Walter Reed Army Institute of Research
Momoh, Mambu M.
Sierra Leone, Freetown
University of Sierra Leone
Sierra Leone, Kenema
Eastern Polytechnic College
Myhrvold, Cameron A.
United States, Cambridge
Broad Institute
United States, Princeton
Princeton University
Naregose, Okonofua Grace
Nigeria, Irrua, Edo State
Irrua Specialist Teaching Hospital
Ndiaye, Tolla D.
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Ndiaye, Mouhamadou D.
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Ndiaye, Aliou R.
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Normandin, Erica
United States, Cambridge
Broad Institute
United States, Boston
Harvard Medical School
Odia, Ikponmwosa
Nigeria, Irrua, Edo State
Irrua Specialist Teaching Hospital
Oguzie, Judith Uche
Nigeria, Ede
Redeemer‘s University
Okogbenin, Sylvanus Akhalufo
Nigeria, Irrua, Edo State
Irrua Specialist Teaching Hospital
Okokhere, Peter O.
Nigeria, Irrua, Edo State
Irrua Specialist Teaching Hospital
Nigeria, Ekpoma
Ambrose Alli University
Okolie, Johnson C.
Nigeria, Ede
Redeemer‘s University
Olawoye, Idowu Bolade
Nigeria, Ede
Redeemer‘s University
Olumade, Testimony
Nigeria, Ede
Redeemer‘s University
Oluniyi, Paul E.
Nigeria, Ede
Redeemer‘s University
Omoregie, Omigie
Nigeria, Irrua, Edo State
Irrua Specialist Teaching Hospital
Nigeria, Yaba, Lagos State
West African Examinations Council
Park, Daniel J.
United States, Cambridge
Broad Institute
Paye, Mariétou Faye
United States, Cambridge
Broad Institute
Petros, Brittany A.
United States, Cambridge
Broad Institute
United States, Cambridge
Massachusetts Institute of Technology
Philippakis, Anthony A.
United States, Cambridge
Broad Institute
Priscilla, Abechi
Nigeria, Ede
Redeemer‘s University
Ricks, Alan
United States, New Haven
Yale University
Rimoin, Anne W.
United States, Los Angeles
University of California, Los Angeles
Sandi, John Demby
Sierra Leone, Freetown
University of Sierra Leone
Schieffelin, John S.
United States, New Orleans
Lsuhsc School of Medicine
Schreiber, Monica
United States, Cambridge
Harvard University
Seck, Mame Cheikh
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Siddiqui, Sameed M.
United States, Cambridge
Broad Institute
United States, Cambridge
Massachusetts Institute of Technology
Siddle, Katherine J.
United States, Cambridge
Broad Institute
Smither, Allison R.
United States, New Orleans
Tulane University School of Medicine
Sy, Mouhamad Demba
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Sy, Ngayo
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Tomkins-Tinch, Christopher H.
United States, Cambridge
Broad Institute
United States, Cambridge
Harvard University
Tomori, Oyewale
Nigeria, Irrua, Edo State
Irrua Specialist Teaching Hospital
Ugwu, Chinedu A.
Nigeria, Ede
Redeemer‘s University
Uwanibe, Jessica N.
Nigeria, Ede
Redeemer‘s University
Uyigue, Eghosasere Anthonia
Nigeria, Irrua, Edo State
Irrua Specialist Teaching Hospital
Vinzé, Anika
United States, Cambridge
Broad Institute
Vodzak, Megan E.
United States, Cambridge
Broad Institute
United States, Chevy Chase
Howard Hughes Medical Institute
Welch, Nicole L.
United States, Cambridge
Broad Institute
United States, Boston
Harvard Medical School
Wurie, Haja Ramatulai
Sierra Leone, Freetown
University of Sierra Leone
Grant, Donald Samuel
Sierra Leone, Kenema
Kenema Government Hospital
Sierra Leone, Freetown
University of Sierra Leone
Ndiaye, Daouda F.
Nigeria, Ede
Redeemer‘s University
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
MacInnis, Bronwyn L.
United States, Cambridge
Broad Institute
Sabeti., Pardis C.
United States, Cambridge
Broad Institute
United States, Chevy Chase
Howard Hughes Medical Institute
United States, Cambridge
Harvard University
United States, Boston
Massachusetts General Hospital
United States, Boston
Massachusetts Consortium on Pathogen Readiness
Happi, Christian Tientcha
Nigeria, Ede
Redeemer‘s University
United States, Cambridge
Harvard University
Statistics
Citations: 5
Authors: 109
Affiliations: 34
Identifiers
Doi:
10.3390/v13081605
ISSN:
19994915
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Multi-countries
Nigeria