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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Ecological genomics of anopheles gambiae along a latitudinal cline: A population-resequencing approach
Genetics, Volume 190, No. 4, Year 2012
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Description
The association between fitness-related phenotypic traits and an environmental gradient offers one of the best opportunities to study the interplay between natural selection and migration. In cases in which specific genetic variants also show such clinal patterns, it may be possible to uncover the mutations responsible for local adaptation. The malaria vector, Anopheles gambiae, is associated with a latitudinal cline in aridity in Cameroon; a large inversion on chromosome 2L of this mosquito shows large differences in frequency along this cline, with high frequencies of the inverted karyotype present in northern, more arid populations and an almost complete absence of the inverted arrangement in southern populations. Here we use a genome resequencing approach to investigate patterns of population divergence along the cline. By sequencing pools of individuals from both ends of the cline as well as in the center of the cline-where the inversion is present in intermediate frequency-we demonstrate almost complete panmixia across collinear parts of the genome and high levels of differentiation in inverted parts of the genome. Sequencing of separate pools of each inversion arrangement in the center of the cline reveals large amounts of gene flux (i.e., gene conversion and double crossovers) even within inverted regions, especially away from the inversion breakpoints. The interplay between natural selection, migration, and gene flux allows us to identify several candidate genes responsible for the match between inversion frequency and environmental variables. These results, coupled with similar conclusions from studies of clinal variation in Drosophila, point to a number of important biological functions associated with local environmental adaptation. © 2012 by the Genetics Society of America.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3316653/bin/supp_190_4_1417__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3316653/bin/supp_111.137794_137794SI.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3316653/bin/supp_111.137794_FigureS1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3316653/bin/supp_111.137794_FigureS2.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3316653/bin/supp_111.137794_TableS1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3316653/bin/supp_111.137794_TableS2.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3316653/bin/supp_111.137794_TableS3.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3316653/bin/supp_111.137794_TableS4.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3316653/bin/supp_111.137794_TableS5.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3316653/bin/supp_111.137794_TableS6.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3316653/bin/supp_111.137794_TableS7.pdf
Authors & Co-Authors
Cheng, Changde
United States, Notre Dame
University of Notre Dame
White, Bradley J.
United States, Notre Dame
University of Notre Dame
United States, Riverside
University of California, Riverside
Kamdem, Colince
Cameroon, Yaounde
Université de Yaoundé I
France, Marseille
Ird Institut de Recherche Pour le Developpement
Mockaitis, Keithanne
United States, Bloomington
Indiana University Bloomington
Costantini, Carlo
France, Marseille
Ird Institut de Recherche Pour le Developpement
Hahn, Matthew W.
United States, Bloomington
Luddy School of Informatics, Computing, and Engineering
Besansky, Nora J.
United States, Notre Dame
University of Notre Dame
Statistics
Citations: 176
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1534/genetics.111.137794
ISSN:
00166731
e-ISSN:
19432631
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Cameroon