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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Incidence of tuberculosis and survival after its diagnosis in patients infected with HIV-1 and HIV-2
AIDS, Volume 18, No. 14, Year 2004
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Description
Background: In sub-Saharan Africa, tuberculosis (TB) is the most frequently diagnosed opportunistic infection and cause of death among HIV-infected patients. HIV-2 has been associated with less immune suppression, slower disease progression and longer survival. Objective: To examine whether the incidence of TB and survival after TB are associated with CD4 cell count rather than HIV type. Methods: Clinical and immunological data were retrospectively evaluated among an open clinic-based cohort of HIV-1- and HIV-2-infected patients to determine incidence of TB (first diagnosis > 28 days after HIV diagnosis) and subsequent mortality. Patients were grouped by CD4 cell count into those with < 200, 200-500 and > 500 × 106 cells/l. Results: Incident TB was diagnosed among 159 of 2012 patients, with 4973 person-years of observation time. In 105/159 (66.0%), the diagnosis was confirmed by direct microscopy or culture. Incidence of TB was highest in the group with < 200 × 106 cells/l (9.1/100 and 8.8/100 person-years in HIV-1 and HIV-2, respectively). Adjusted for CD4 cell count, there was no significant difference in incidence or mortality following TB between HIV-1- and HIV-2-infected patients. Mortality rate was higher inthose with incident TB and HIV infection, most markedly in the group with the highest CD4 cell count (hazard ratio, 10.0; 95% confidence interval, 5.1-19.7). Conclusion: Adjusted for CD4 cell count, incidence of TB was similar among HIV-1-and HIV-2-infected patients. Mortality rates after TB diagnosis were similar in both groups and high compared with those without TB. © 2004 Lippincott Williams & Wilkins.
Authors & Co-Authors
van der Sande, Marianne A.B.
Unknown Affiliation
Schim-van der Loeff, Maarten Franciscus
Unknown Affiliation
Bennett, Rachel C.
Unknown Affiliation
Dowling, Mary
Unknown Affiliation
Aveika, Akum Akum
Unknown Affiliation
Togun, Toyin Omotayo
Unknown Affiliation
Sabally, Saihou
Unknown Affiliation
Jeffries, David J.
Unknown Affiliation
Adegbola, Richard A.
Unknown Affiliation
Sarge-Njie, Ramu
Unknown Affiliation
Jaye, Assan
Unknown Affiliation
Corrah, Tumani P.
Unknown Affiliation
McConkey, Samuel J.
Unknown Affiliation
Whittle, Hilton C.
Unknown Affiliation
Statistics
Citations: 69
Authors: 14
Affiliations: 3
Identifiers
Doi:
10.1097/00002030-200409240-00009
Research Areas
Environmental
Health System And Policy
Infectious Diseases
Study Design
Cohort Study