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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Full genome analysis of hepatitis B virus genotype E strains from South-Western Africa and Madagascar reveals low genetic variability
Journal of Medical Virology, Volume 77, No. 1, Year 2005
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Description
The eight genotypes of hepatitis B virus (HBV), A-H, have a characteristic geographical distribution. The high prevalence of genotype E within a wide expanse of Africa makes it important to characterize this genotype. Although the preS/S region of a large number of genotype E isolates has been sequenced, to date only eight complete genotype E genomes have been published. The aim of this study, therefore, was to sequence and characterize the complete genome of genotype E isolates obtained from geographically distinct regions in Africa, including Namibia, Angola, and Madagascar. The nine newly sequenced genotype E isolates were closely related with an intragroup nucleotide divergence of 1.2%, reflecting their close geographical origin. All genotype E strains have the same characteristics, an in-frame deletion of three nucleotides (one amino acid) in the 5′ pre-S1, a signature pattern of amino acids in the pre-S1 region and the serological subtype ayw4. In addition, we have identified another unique attribute of genotype E strains, the introduction of another start codon Met83 in the pre-S1 region that may result in the translation of an elongated middle hepatitis B surface protein (MHBs). © 2005 Wiley-Liss, Inc.
Authors & Co-Authors
Kramvis, Anna
South Africa, Tygerberg
South African Medical Research Council
South Africa, Johannesburg
School of Clinical Medicine
Restorp, Karin
Sweden, Solna
Swed. Inst. for Infect. Dis. Cotrol
Norder, Heléne
Sweden, Solna
Swed. Inst. for Infect. Dis. Cotrol
Botha, Johan F.
South Africa, Tygerberg
South African Medical Research Council
Magnius, Lars O.
Sweden, Solna
Swed. Inst. for Infect. Dis. Cotrol
Kew, Michael Charles
South Africa, Tygerberg
South African Medical Research Council
Statistics
Citations: 77
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1002/jmv.20412
ISSN:
01466615
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Angola
Madagascar
Namibia