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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Investigation of SARS-CoV-2 faecal shedding in the community: a prospective household cohort study (COVID-LIV) in the UK
BMC Infectious Diseases, Volume 21, No. 1, Article 784, Year 2021
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Description
Background: SARS-CoV-2 is frequently shed in the stool of patients hospitalised with COVID-19. The extent of faecal shedding of SARS-CoV-2 among individuals in the community, and its potential to contribute to spread of disease, is unknown. Methods: In this prospective, observational cohort study among households in Liverpool, UK, participants underwent weekly nasal/throat swabbing to detect SARS-CoV-2 virus, over a 12-week period from enrolment starting July 2020. Participants that tested positive for SARS-CoV-2 were asked to provide a stool sample three and 14 days later. In addition, in October and November 2020, during a period of high community transmission, stool sampling was undertaken to determine the prevalence of SARS-CoV-2 faecal shedding among all study participants. SARS-CoV-2 RNA was detected using Real-Time PCR. Results: A total of 434 participants from 176 households were enrolled. Eighteen participants (4.2%: 95% confidence interval [CI] 2.5–6.5%) tested positive for SARS-CoV-2 virus on nasal/throat swabs and of these, 3/17 (18%: 95% CI 4–43%) had SARS-CoV-2 detected in stool. Two of three participants demonstrated ongoing faecal shedding of SARS-CoV-2, without gastrointestinal symptoms, after testing negative for SARS-CoV-2 in respiratory samples. Among 165/434 participants without SARS-CoV-2 infection and who took part in the prevalence study, none had SARS-CoV-2 in stool. There was no demonstrable household transmission of SARS-CoV-2 among households containing a participant with faecal shedding. Conclusions: Faecal shedding of SARS-CoV-2 occurred among community participants with confirmed SARS-CoV-2 infection. However, during a period of high community transmission, faecal shedding of SARS-CoV-2 was not detected among participants without SARS-CoV-2 infection. It is unlikely that the faecal-oral route plays a significant role in household and community transmission of SARS-CoV-2. © 2021, The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC8352155/bin/12879_2021_6443_MOESM1_ESM.pdf
Authors & Co-Authors
Vaselli, Natasha Marcella
United Kingdom, Liverpool
University of Liverpool
Subramaniam, Krishanthi S.
United Kingdom, Liverpool
University of Liverpool
Adams, E. R.
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Turtle, Lance C.W.
United Kingdom, Liverpool
University of Liverpool
Iturriza-Gómara, Miren
United Kingdom, Liverpool
University of Liverpool
Switzerland, Geneva
Path
Solomon, Tom
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Liverpool
The Walton Centre Nhs Foundation Trust
Cunliffe, Nigel A.
United Kingdom, Liverpool
University of Liverpool
French, N.
United Kingdom, Liverpool
University of Liverpool
Hungerford, Daniel
United Kingdom, Liverpool
University of Liverpool
Vivancos, R.
Unknown Affiliation
Gabbay, Mark Benjamin
Unknown Affiliation
Buchan, Iain Edward
Unknown Affiliation
Carrol, Enitan D.
Unknown Affiliation
Gamble, C. L.
Unknown Affiliation
Goodwin, Lynsey C.
Unknown Affiliation
Donohue, Chloe
Unknown Affiliation
Marsh, Laura C.
Unknown Affiliation
Greenhalf, William
Unknown Affiliation
Naisbitt, Dean John
Unknown Affiliation
Aston, Stephen J.
Unknown Affiliation
Howarth, Deborah
Unknown Affiliation
Lowe, Jenna
Unknown Affiliation
Jones, Jayne
Unknown Affiliation
Edwards, Thomas J.
Unknown Affiliation
Williams, Christopher Thomas
Unknown Affiliation
Byrne, Rachel L.
Unknown Affiliation
Garrod, Gala
Unknown Affiliation
Owen, Sophie I.
Unknown Affiliation
Jones, Ashley P.
Unknown Affiliation
Statistics
Citations: 11
Authors: 29
Affiliations: 4
Identifiers
Doi:
10.1186/s12879-021-06443-7
ISSN:
14712334
Research Areas
Covid
Health System And Policy
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative