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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Inhibitory effect and transcriptional impact of berberine and evodiamine on human white preadipocyte differentiation
Fitoterapia, Volume 81, No. 4, Year 2010
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Description
It has been reported that the botanical alkaloids, berberine and evodiamine inhibit mouse preadipocyte 3T3-L1 differentiation. The aim of this study was to investigate the effect and transcriptional impact of berberine and evodiamine individually and in combination on human white preadipocyte (HWP) differentiation. We have shown that treatment with 8 μM berberine or 4 μM evodiamine resulted in a major inhibition of HWP differentiation accompanied by up-regulation of both GATA binding protein 2 and 3 (GATA-2 and GATA-3) mRNA and protein expression, suggesting that both compounds may have excellent potential as agents to prevent obesity. © 2009 Elsevier B.V.
Authors & Co-Authors
Fahmy, Hesham Tawfik Youssef
United States, Brookings
South Dakota State University
Zjawiony, Jordan
United States, University
University of Mississippi, Research Institute Pharmaceutical Science
Davies, Gareth E.
United States, Brookings
South Dakota State University
United States, Sioux Falls
Avera Health
United States, Vermillion
University of South Dakota
Statistics
Citations: 41
Authors: 3
Affiliations: 4
Identifiers
Doi:
10.1016/j.fitote.2009.09.012
ISSN:
0367326X
Research Areas
Noncommunicable Diseases