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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Metabolic Syndrome and Risk of Acute Myocardial Infarction. A Case-Control Study of 26,903 Subjects From 52 Countries
Journal of the American College of Cardiology, Volume 55, No. 21, Year 2010
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Description
Objectives: This study examines the risk of acute myocardial infarction (MI) conferred by the metabolic syndrome (MS) and its individual factors in multiple ethnic populations. Background: The risk of the MS on MI has not been well characterized, especially in multiple ethnic groups. Methods: Participants in the INTERHEART study (n = 26,903) involving 52 countries were classified using the World Health Organization (WHO) and International Diabetes Federation (IDF) criteria for MS, and their odds ratios (ORs) for MI were compared with the individual MS component factors. Results: The MS is associated with an increased risk of MI, both using the WHO (OR: 2.69; 95% confidence interval [CI]: 2.45 to 2.95) and IDF (OR: 2.20; 95% CI: 2.03 to 2.38) definitions, with corresponding population attributable risks of 14.5% (95% CI: 12.7% to 16.3%) and 16.8% (95% CI: 14.8% to 18.8%), respectively. The associations are directionally similar across all regions and ethnic groups. Using the WHO definition, the association with MI by the MS is similar to that of diabetes mellitus (OR: 2.72; 95% CI: 2.53 to 2.92) and hypertension (OR: 2.60; 95% CI: 2.46 to 2.76), and significantly stronger than that of the other component risk factors. The clustering of ≥3 risk factors with subthreshold values is associated with an increased risk of MI (OR: 1.50; 95% CI: 1.24 to 1.81) compared with having component factors with "normal" values. The IDF definition showed similar results. Conclusions: In this large-scale, multi-ethnic, international investigation, the risk of MS on MI is generally comparable to that conferred by some, but not all, of its component risk factors. The characterization of risk factors, especially continuous variables, as dichotomous will underestimate risk and decrease the magnitude of association between MS and MI. © 2010 American College of Cardiology Foundation.
Authors & Co-Authors
Mente, Andrew
Canada, Hamilton
Population Health Research Institute, Ontario
Canada, Hamilton
Mcmaster University
Yusuf, Salim N.
Canada, Hamilton
Population Health Research Institute, Ontario
Canada, Hamilton
Mcmaster University
Islam, Shofiqul
Canada, Hamilton
Population Health Research Institute, Ontario
McQueen, Matthew J.
Canada, Hamilton
Population Health Research Institute, Ontario
Canada, Hamilton
Mcmaster University
Tanomsup, Supachai
Thailand, Bangkok
Ramathibodi Hospital
Onen, Churchill Lukwiya
Botswana, Gaborone
Gaborone Private Hospital
Rangarajan, Sumathy
Canada, Hamilton
Population Health Research Institute, Ontario
Gerstein, Hertzel C.
Canada, Hamilton
Population Health Research Institute, Ontario
Canada, Hamilton
Mcmaster University
Anand, Sonia S.
Canada, Hamilton
Population Health Research Institute, Ontario
Canada, Hamilton
Mcmaster University
Statistics
Citations: 242
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1016/j.jacc.2009.12.053
ISSN:
07351097
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Case-Control Study