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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Antidiabetic effect of plumbagin isolated from Plumbago zeylanica L. root and its effect on GLUT4 translocation in streptozotocin-induced diabetic rats
Food and Chemical Toxicology, Volume 50, No. 12, Year 2012
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Description
Plumbago zeylanica L. root is widely used in Indian medicine to treat diabetes mellitus. The aim of the present investigation was to evaluate the antidiabetic effects of plumbagin isolated from P. zeylanica L. root and its effect on GLUT4 translocation in STZ-induced diabetic rats. Plumbagin (15 and 30 mg/kg. b. wt) was orally administered to STZ-induced diabetic rats for 28. days. An oral glucose tolerance test was performed on 21st day. The effect of plumbagin on body weight, blood glucose, plasma insulin, total protein, urea, creatinine, liver glycogen, plasma enzymes (SGOT, SGPT and ALP) and carbohydrate metabolism enzymes (glucose-6-phosphatase, fructose-1,6-bisphosphatase and hexokinase) were investigated. GLUT4 mRNA and protein expression in skeletal muscles were also studied. Plumbagin significantly reduced the blood glucose and significantly altered all other biochemical parameters to near normal. Further, plumbagin increased the activity of hexokinase and decreased the activities of glucose-6-phosphatase and fructose-1,6-bisphosphatase significantly in treated diabetic rats. Enhanced GLUT4 mRNA and protein expression were observed in diabetic rats after treatment with plumbagin. The results indicated that plumbagin enhanced GLUT4 translocation and contributed to glucose homeostasis. It could be further probed for use as a drug to treat diabetes. © 2012 Elsevier Ltd.
Authors & Co-Authors
Sunil, Christudas
India, Chennai
Loyola College, Chennai
Duraipandiyan, V.
India, Chennai
Loyola College, Chennai
Saudi Arabia, Riyadh
College of Sciences
Agastian, Paul
India, Chennai
Loyola College, Chennai
Ignacimuthu, Savarimuthu J.
India, Chennai
Loyola College, Chennai
Statistics
Citations: 106
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/j.fct.2012.08.046
ISSN:
02786915
e-ISSN:
18736351
Research Areas
Health System And Policy
Noncommunicable Diseases