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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Sex-related differences in patients with coronavirus disease 2019: Results of the Cardio-COVID-Italy multicentre study
Journal of Cardiovascular Medicine, Volume 23, No. 4, Year 2022
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Description
IntroductionThe role of sex compared to comorbidities and other prognostic variables in patients with coronavirus disease (COVID-19) is unclear.MethodsThis is a retrospective observational study on patients with COVID-19 infection, referred to 13 cardiology units. The primary objective was to assess the difference in risk of death between the sexes. The secondary objective was to explore sex-based heterogeneity in the association between demographic, clinical and laboratory variables, and patients' risk of death.ResultsSeven hundred and one patients were included: 214 (30.5%) women and 487 (69.5%) men. During a median follow-up of 15-days, deaths occurred in 39 (18.2%) women and 126 (25.9%) men. In a multivariable Cox regression model, men had a nonsignificantly higher risk of death vs. women (P = 0.07).The risk of death was more than double in men with a low lymphocytes count as compared with men with a high lymphocytes count [overall survival hazard ratio (OS-HR) 2.56, 95% confidence interval (CI) 1.72-3.81]. In contrast, lymphocytes count was not related to death in women (P=0.03).Platelets count was associated with better outcome in men (OS-HR for increase of 50-×-103units: 0.88 95% CI 0.78-1.00) but not in women. The strength of association between higher PaO2/FiO2ratio and lower risk of death was larger in women (OS-HR for increase of 50-mmHg/%: 0.72, 95% CI 0.59-0.89) vs. men (OS-HR: 0.88, 95% CI 0.80-0.98; P-=-0.05).ConclusionsPatients' sex is a relevant variable that should be taken into account when evaluating risk of death from COVID-19. There is a sex-based heterogeneity in the association between baseline variables and patients' risk of death. © 2022 Lippincott Williams and Wilkins. All rights reserved.
Authors & Co-Authors
Specchia, Claudia
Italy, Brescia
Università Degli Studi Di Brescia
Agostoni, Piergiuseppe
Italy, Milan
Irccs Centro Cardiologico Monzino
Carugo, Stefano
Italy, Milan
Ospedale San Paolo
Guazzi, Marco
Italy, Milan
Università Degli Studi Di Milano
Italy, San Donato Milanese
Gruppo Ospedaliero San Donato
Mortara, Andrea
Italy, Monza
Policlinico Di Monza
PIEPOLI, MASSIMO Francesco
Italy, Piacenza
Ospedale Guglielmo da Saliceto
Italy, Pisa
Sant'anna Scuola Universitaria Superiore Pisa
Porto, Italo
Italy, Genoa
Scuola Di Scienze Mediche e Farmaceutiche, Università Degli Studi Di Genova
Volterrani, Maurizio
Italy, Rome
Irccs San Raffaele Pisana
Ameri, Pietro
Italy, Genoa
Scuola Di Scienze Mediche e Farmaceutiche, Università Degli Studi Di Genova
Gnecchi, Massimiliano
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Italy, Pavia
Università Degli Studi Di Pavia
Leonardi, Sergio
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Italy, Pavia
Università Degli Studi Di Pavia
Iorio, Anna Maria Aria
Italy, Bergamo
Papa Giovanni Xxiii Hospital
Camporotondo, Rita
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Giovinazzo, Stefano
Italy, Genoa
Scuola Di Scienze Mediche e Farmaceutiche, Università Degli Studi Di Genova
Mapelli, Massimo
Italy, Milan
Irccs Centro Cardiologico Monzino
Pozzi, Andrea
Italy, Bergamo
Papa Giovanni Xxiii Hospital
Adamo, Marianna
Italy, Brescia
Spedali Civili Di Brescia
Tomasoni, Daniela
Italy, Brescia
Spedali Civili Di Brescia
Senni, Michele
Italy, Bergamo
Papa Giovanni Xxiii Hospital
Metra, Marco
Italy, Brescia
Spedali Civili Di Brescia
Statistics
Citations: 3
Authors: 20
Affiliations: 19
Identifiers
Doi:
10.2459/JCM.0000000000001261
ISSN:
15582027
Research Areas
Covid
Environmental
Genetics And Genomics
Study Design
Cohort Study
Participants Gender
Male
Female