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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Human papillomavirus distribution in invasive cervical carcinoma in sub-Saharan Africa: Could HIV explain the differences?
Tropical Medicine and International Health, Volume 17, No. 12, Year 2012
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Description
Objectives To describe human papillomavirus (HPV) distribution in invasive cervical carcinoma (ICC) from Mali and Senegal and to compare type-specific relative contribution among sub-Saharan African (SSA) countries. Methods A multicentric study was conducted to collect paraffin-embedded blocks of ICC. Polymerase chain reaction, DNA enzyme immunoassay and line probe assay were performed for HPV detection and genotyping. Data from SSA (Mozambique, Nigeria and Uganda) and 35 other countries were compared. Results One hundred and sixty-four ICC cases from Mali and Senegal were tested from which 138 were positive (adjusted prevalence=86.8%; 95% CI=79.7-91.7%). HPV16 and HPV18 accounted for 57.2% of infections and HPV45 for 16.7%. In SSA countries, HPV16 was less frequent than in the rest of the world (49.4%vs. 62.6%; P<0.0001) but HPV18 and HPV45 were two times more frequent (19.3%vs. 9.4%; P<0.0001 and 10.3%vs. 5.6%; P<0.0001, respectively). There was an ecological correlation between HIV prevalence and the increase of HPV18 and the decrease of HPV45 in ICC in SSA (P = 0.037 for both). Conclusion HPV16/18/45 accounted for two-thirds of the HPV types found in invasive cervical cancer in Mali and Senegal. Our results suggest that HIV may play a role in the underlying HPV18 and HPV45 contribution to cervical cancer, but further studies are needed to confirm this correlation. © 2012 Blackwell Publishing Ltd.
Authors & Co-Authors
Ndiaye, Cathy
Canada, Montreal
University of Montreal
Canada, Montreal
Chu Sainte-justine - le Centre Hospitalier Universitaire Mère-enfant
Alemany, Laia
Spain, Hospitalet de Llobregat
Institute Catala Oncologia
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Ndiaye, Nafissatou
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Kamaté, Bakarou
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Diop, Yankhoba C.
Senegal, Dakar
Hopital Principal de Dakar
Odida, Michael
Uganda, Kampala
Makerere University
Banjo, Kunbi
Nigeria, Lagos
Lagos University Teaching Hospital
Tous, Sara
Spain, Hospitalet de Llobregat
Institute Catala Oncologia
Klaustermeier, Jo Ellen
Spain, Hospitalet de Llobregat
Institute Catala Oncologia
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Clavero, Omar
Spain, Hospitalet de Llobregat
Institute Catala Oncologia
Castellsagué, X.
Spain, Hospitalet de Llobregat
Institute Catala Oncologia
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Bosch, Francisco Xavier
Spain, Hospitalet de Llobregat
Institute Catala Oncologia
Spain, Zaragoza
Red Tematica de Investigacion Cooperativa en Cancer
Trottier, Helen
Canada, Montreal
University of Montreal
Canada, Montreal
Chu Sainte-justine - le Centre Hospitalier Universitaire Mère-enfant
de Sanjosé, Sílvia
Spain, Hospitalet de Llobregat
Institute Catala Oncologia
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Statistics
Citations: 44
Authors: 14
Affiliations: 10
Identifiers
Doi:
10.1111/tmi.12004
ISSN:
13602276
e-ISSN:
13653156
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Mali
Mozambique
Nigeria
Senegal
Uganda