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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Kisspeptin restores pulsatile LH secretion in patients with neurokinin B signaling deficiencies: Physiological, pathophysiological and therapeutic implications
Neuroendocrinology, Volume 97, No. 2, Year 2013
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Description
Pulsatile gonadotropin-releasing hormone (GnRH) is crucial to normal reproductive function and abnormalities in pulse frequency give rise to reproductive dysfunction. Kisspeptin and neurokinin B (NKB), neuropeptides secreted by the same neuronal population in the ventral hypothalamus, have emerged recently as critical central regulators of GnRH and thus gonadotropin secretion. Patients with mutations resulting in loss of signaling by either of these neuroendocrine peptides fail to advance through puberty but the mechanisms mediating this remain unresolved. We report here that continuous kisspeptin infusion restores gonadotropin pulsatility in patients with loss-of-function mutations in NKB (TAC3) or its receptor (TAC3R), indicating that kisspeptin on its own is sufficient to stimulate pulsatile GnRH secretion. Moreover, our findings suggest that NKB action is proximal to kisspeptin in the reproductive neuroendocrine cascade regulating GnRH secretion, and may act as an autocrine modulator of kisspeptin secretion. The ability of continuous kisspeptin infusion to induce pulsatile gonadotropin secretion further indicates that GnRH neurons are able to set up pulsatile secretion in the absence of pulsatile exogenous kisspeptin. Copyright © 2012 S. Karger AG, Basel.
Authors & Co-Authors
Young, Jacques M.
France, Gif-sur-yvette
Université Paris-saclay
France, Le Kremlin-bicetre
Service D'endocrinologie et Des Maladies de la Reproduction
George, Jyothis T.
United Kingdom, Edinburgh
Mrc Human Reproductive Sciences Unit
Tello, Javier A.
United Kingdom, Edinburgh
Mrc Human Reproductive Sciences Unit
United Kingdom, Edinburgh
The University of Edinburgh
Francou, Bruno
France, Gif-sur-yvette
Université Paris-saclay
France, Paris
Inserm
France, Le Kremlin-bicetre
Hopital de Bicetre
Bouligand, Jérôme
France, Gif-sur-yvette
Université Paris-saclay
France, Paris
Inserm
France, Le Kremlin-bicetre
Hopital de Bicetre
Guiochon-Mantel, Anne
France, Gif-sur-yvette
Université Paris-saclay
France, Paris
Inserm
France, Le Kremlin-bicetre
Hopital de Bicetre
Brailly-Tabard, Sylvie
France, Gif-sur-yvette
Université Paris-saclay
France, Paris
Inserm
France, Le Kremlin-bicetre
Hopital de Bicetre
Anderson, Richard A.A.
United Kingdom, Edinburgh
Mrc Human Reproductive Sciences Unit
Millar, Robert P.
United Kingdom, Edinburgh
Mrc Human Reproductive Sciences Unit
South Africa, Pretoria
University of Pretoria
Statistics
Citations: 142
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1159/000336376
ISSN:
00283835
e-ISSN:
14230194
Research Areas
Sexual And Reproductive Health
Study Design
Cross Sectional Study