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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Extensive regulation of the non-coding transcriptome by hypoxia: Role of HIF in releasing paused RNApol2
EMBO Reports, Volume 15, No. 1, Year 2014
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Description
Hypoxia is central to both ischaemic and neoplastic diseases. However, the non-coding transcriptional response to hypoxia is largely uncharacterized. We undertook integrated genomic analyses of both non-coding and coding transcripts using massively parallel sequencing and interfaced this data with pan-genomic analyses of hypoxia-inducible factor (HIF) and RNApol2 binding in hypoxic cells. These analyses revealed that all classes of RNA are profoundly regulated by hypoxia and implicated HIF as a major direct regulator of both the non-coding and coding transcriptome, acting predominantly through release of pre-bound promoter-paused RNApol2. These findings indicate that the transcriptional response to hypoxia is substantially more extensive than previously considered. © 2013 The Authors.
Authors & Co-Authors
Choudhry, Hani M.Z.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Saudi Arabia, Jeddah
King Abdulaziz University
Schödel, Johannes
United Kingdom, Oxford
Nuffield Department of Medicine
Germany, Erlangen
Friedrich-alexander-universität Erlangen-nürnberg
Oikonomopoulos, Spyros
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Camps, Carme
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Grampp, Steffen
Germany, Erlangen
Friedrich-alexander-universität Erlangen-nürnberg
Harris, Adrian L.
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
Ratcliffe, Peter J.
United Kingdom, Oxford
Nuffield Department of Medicine
Ragoussis, Ioannis
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Canada, Montreal
Université Mcgill
Greece, Vari
Biomedical Sciences Research Center Alexander Fleming
Mole, David Robert
United Kingdom, Oxford
Nuffield Department of Medicine
Statistics
Citations: 151
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1002/embr.201337642
ISSN:
1469221X
e-ISSN:
14693178