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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A clinical trial of prime-boost immunisation with the candidate malaria vaccines RTS,S/AS02A and MVA-CS
Vaccine, Volume 24, No. 15, Year 2006
Notification
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Description
Heterologous prime-boost immunisation with RTS,S/AS02A and the poxvirus MVA-CS was evaluated in 18 healthy malaria-naïve subjects in Oxford. Both priming with RTS,S and boosting MVA-CS, and the reverse, were found to be safe and well tolerated. T cell responses as measured by IFN-γ ex vivo ELISPOT were induced, but the responses were low to moderate in both groups, with heterologous boosting yielding only small increments in T cell immunogenicity and no increased antibody response. Protection against 3D7 Plasmodium falciparum sporozoite challenge 4 weeks after the final vaccination was equal for both regimens at 33% (95% C.I. 4.3-77.7%), with one subject remaining fully protected on rechallenge at 5 months. © 2006 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Dunachie, Susanna J.
United Kingdom, Oxford
Churchill Hospital
Walther, Michael
United Kingdom, Oxford
Churchill Hospital
Vuola, Jenni M.
United Kingdom, Oxford
Churchill Hospital
Finland, Espoo
Glaxosmithkline oy
Webster, Daniel Peter
United Kingdom, Oxford
Churchill Hospital
Keating, Sheila Marie
United Kingdom, Oxford
Churchill Hospital
Berthoud, Tamara Katherine
United Kingdom, Oxford
Churchill Hospital
Andrews, Laura
United Kingdom, Oxford
Churchill Hospital
Bejon, Philip A.
United Kingdom, Oxford
Churchill Hospital
Poulton, Ian D.
United Kingdom, Oxford
Churchill Hospital
Butcher, Geoffrey A.
United Kingdom, London
Imperial College London
Watkins, Katherine R.
United Kingdom, Oxford
Churchill Hospital
Sinden, Robert E.
United Kingdom, London
Imperial College London
Leach, Amanda
Belgium, Rixensart
Glaxosmithkline Biologicals S.a.
Moris, Philippe J.
Belgium, Rixensart
Glaxosmithkline Biologicals S.a.
Tornieporth, Nadia Gabriela
Belgium, Rixensart
Glaxosmithkline Biologicals S.a.
Schneider, Jörg
Unknown Affiliation
Dubovsky, Filip
United States, Bethesda
Path Malaria Vaccine Initiative
Tierney, Eveline Lee
United States, Bethesda
Path Malaria Vaccine Initiative
Williams, Jack L.
United States, Silver Spring
Walter Reed Army Institute of Research
Gray Heppner, D.
United States, Silver Spring
Walter Reed Army Institute of Research
Gilbert, Sarah C.
United Kingdom, Oxford
Churchill Hospital
Cohen, Joe D.
Belgium, Rixensart
Glaxosmithkline Biologicals S.a.
Hill, Adrian V. S.
United Kingdom, Oxford
Churchill Hospital
Statistics
Citations: 85
Authors: 23
Affiliations: 6
Identifiers
Doi:
10.1016/j.vaccine.2005.12.041
ISSN:
0264410X
Research Areas
Infectious Diseases