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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
High prevalence of glucose-6-phosphate dehydrogenase deficiency without gene mutation suggests a novel genetic mechanism predisposing to ketosis-prone diabetes
Journal of Clinical Endocrinology and Metabolism, Volume 90, No. 8, Year 2005
Notification
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Description
Context: Ketosis-prone diabetes (KPD) is mostly observed in males of West African descent and is characterized by phasic or permanent insulin dependence without apparent autoimmune process. Objective: KPD subjects display a propensity to hyperglycemia-induced acute insulin deficiency, suggesting that they exhibit a propensity to oxidative stress in β-cells. The enzyme glucose-6-phosphate dehydrogenase (G6PD) is a defense mechanism against oxidative stress, and G6PD deficiency, an X-linked genetic disorder with male predominance, is frequent in West Africans. We hypothesized that mutations in the G6PD gene could predispose to KPD. Design: We studied G6PD erythrocyte enzyme activity and the insulin secretory reserve (glucagon-stimulated C peptide) in a cohort of hospitalized West Africans with KPD (n = 59) or type 2 diabetes (T2DM; n = 59) and in normoglycemic controls (n = 55). We also studied the G6PD gene in an extended population of KPD patients (n = 100), T2DM patients (n = 59), and controls (n = 85). Results: The prevalence of G6PD deficiency was higher in KPD than in T2DM and controls (42.3%; 16.9%; 16.4%; P = 0.01). In KPD, but not in T2DM, insulin deficiency was proportional to the decreased G6PD activity (r = 0.33; P = 0.04). We found no increase in the prevalence of G6PD gene mutations in KPD compared with T2DM and controls. Rather, we found a 20.3% prevalence of G6PD deficiency in KPD without gene mutation. Conclusions: This study suggests that 1) G6PD deficiency alone is not causative of KPD; and 2) alterations in genes controlling both insulin secretion and G6PD-mediated antioxidant defenses may contribute to the predisposition to KPD in West Africans. Copyright © 2005 by The Endocrine Society.
Authors & Co-Authors
Sobngwi, Eugène
France, Paris
Université Paris Cité
Gautier, Jean François
France, Paris
Université Paris Cité
France, Paris
Inserm
Riveline, Jean Pierre
France, Corbeil-essonnes
Centre Hospitalier Sud-francilien
Vexiau, Patrick
France, Paris
Université Paris Cité
France, Paris
Inserm
Leal, Suzanne M.
United States, Houston
Baylor College of Medicine
Mauvais-Jarvis, Franck
France, Paris
Université Paris Cité
France, Paris
Inserm
United States, San Francisco
University of California, San Francisco
United States, Houston
Baylor College of Medicine
Statistics
Citations: 71
Authors: 6
Affiliations: 6
Identifiers
Doi:
10.1210/jc.2004-2545
ISSN:
0021972X
Research Areas
Cancer
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Male