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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The global distribution of the Duffy blood group
Nature Communications, Volume 2, No. 1, Article 266, Year 2011
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Description
Blood group variants are characteristic of population groups, and can show conspicuous geographic patterns. Interest in the global prevalence of the Duffy blood group variants is multidisciplinary, but of particular importance to malariologists due to the resistance generally conferred by the Duffy-negative phenotype against Plasmodium vivax infection. Here we collate an extensive geo-database of surveys, forming the evidence-base for a multi-locus Bayesian geostatistical model to generate global frequency maps of the common Duffy alleles to refine the global cartography of the common Duffy variants. We show that the most prevalent allele globally was FY*A, while across sub-Saharan Africa the predominant allele was the silent FY*BES variant, commonly reaching fixation across stretches of the continent. The maps presented not only represent the first spatially and genetically comprehensive description of variation at this locus, but also constitute an advance towards understanding the transmission patterns of the neglected P. vivax malaria parasite. © 2011 Macmillan Publishers Limited. All rights reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3074097/bin/ncomms1265-s1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3074097/bin/ncomms1265-s2.xls
Authors & Co-Authors
Howes, Rosalind E.
United Kingdom, Oxford
University of Oxford
Patil, Anand Prabhakar
United Kingdom, Oxford
University of Oxford
Piel, Frédéric Bernard
United Kingdom, Oxford
University of Oxford
Nyangiri, Oscar Asanya
Kenya, Kilifi
Centre for Geographic Medicine Research
Kabaria, Caroline W.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Gething, Peter W.
United Kingdom, Oxford
University of Oxford
Zimmerman, Peter A.
United States, Cleveland
Case School of Medicine
Barnadas, Céline
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Beall, Cynthia M.
United States, Cleveland
Case Western Reserve University
Gebremedhin, Amha
Ethiopia, Addis Ababa
School of Medicine
Ménard, Didier
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Williams, Thomas Neil
Kenya, Kilifi
Centre for Geographic Medicine Research
Weatherall, David J.
United Kingdom, Oxford
John Radcliffe Hospital
Hay, Simon I.
United Kingdom, Oxford
University of Oxford
Statistics
Citations: 316
Authors: 14
Affiliations: 9
Identifiers
Doi:
10.1038/ncomms1265
e-ISSN:
20411723
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study