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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
A group specific anamnestic immune reaction against HIV-1 induced by a candidate vaccine against AIDS
Nature, Volume 332, No. 6166, Year 1988
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Description
The first experimental immunization of humans against the AIDS retrovirus, HIV-1, was started in a series of HIV seronegative, healthy volunteers in November 19861. For the primary vaccination recombinant vaccinia virus (V25)2 expressing the complete gp160 env protein3 of the HTLV-IIIB strain4,5 of HIV-1 was introduced by scarification. This elicited a weak primary response which we subseqently attempted to enhance by additional immunizations (boosting), using four different immunization protocols. We report here that intravenous injection of paraformaldehyde-fixed autologous cells infected in vitro with V25 (individual D.Z.) gave the best results. This individual received second and third boosts of intramuscular gp160 derived from an HTLV-IIIB clone using the hybrid vaccinia virus/bacteriophage T7 expression system6. An anamnestic humoral and cellular immune reaction was achieved for over one year after the original vaccination, with high levels of antibodies to the viral envelope, and neutralizing antibodies against divergent HIV-1 strains such as HTLV-III B4,5,7 and HTLV-IIIRF (also called HTLV-III HAT)3,5 after the first boost. In addition, group-specific cell-mediated immunity and cell-mediated cytotoxicity against infected T4 cells were obtained after the primary vaccine and enhanced by the boosts. Finally, skin tests showed both immediate and delayed hypersensitivity to gp160 in vivo. Although this protocol is not practical for a large scale vaccine trial, our results show for the first time that an immune state against HIV can be obtained in man. © 1988 Nature Publishing Group.
Authors & Co-Authors
Zagury, Daniel
France, Reims
Institut Jean-godinot
Bernard, Jacky
France, Reims
Institut Jean-godinot
Cheynier, Rémi
France, Reims
Institut Jean-godinot
Desportes, Isabelle
France, Reims
Institut Jean-godinot
Léonard, Régine
France, Reims
Institut Jean-godinot
Fouchard, Michelle
France, Reims
Institut Jean-godinot
Réveil, Brigitte
France, Reims
Institut Jean-godinot
Ittelé, Daniéle
France, Reims
Institut Jean-godinot
Lurhuma, Zirimwabagangabo
Democratic Republic Congo
Cliniques Universitaires
Mbayo, Kalumbu
Democratic Republic Congo
Cliniques Universitaires
Wane, Justin
Democratic Republic Congo
Cliniques Universitaires
Salaün, Jean Jacques
Democratic Republic Congo, Kinshasa
Institut National de Recherche Biomédicale
Goussard, Bernard
Democratic Republic Congo, Kinshasa
Institut National de Recherche Biomédicale
Dechazal, Loic
Democratic Republic Congo, Kinshasa
Institut National de Recherche Biomédicale
Burny, Arséne
Belgium, Brussels
Université Libre de Bruxelles
Nara, Peter L.
United States, Rockville
National Cancer Institute Nci
Gallo, Robert C.
United States, Rockville
National Cancer Institute Nci
Statistics
Citations: 163
Authors: 17
Affiliations: 5
Identifiers
Doi:
10.1038/332728a0
ISSN:
00280836
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health