Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
SARS-CoV-2 infection increases risk of acute kidney injury in a bimodal age distribution
BMC Nephrology, Volume 23, No. 1, Article 63, Year 2022
Notification
URL copied to clipboard!
Description
Background: Hospitalized patients with SARS-CoV2 develop acute kidney injury (AKI) frequently, yet gaps remain in understanding why adults seem to have higher rates compared to children. Our objectives were to evaluate the epidemiology of SARS-CoV2-related AKI across the age spectrum and determine if known risk factors such as illness severity contribute to its pattern. Methods: Secondary analysis of ongoing prospective international cohort registry. AKI was defined by KDIGO-creatinine only criteria. Log-linear, logistic and generalized estimating equations assessed odds ratios (OR), risk differences (RD), and 95% confidence intervals (CIs) for AKI and mortality adjusting for sex, pre-existing comorbidities, race/ethnicity, illness severity, and clustering within centers. Sensitivity analyses assessed different baseline creatinine estimators. Results: Overall, among 6874 hospitalized patients, 39.6% (n = 2719) developed AKI. There was a bimodal distribution of AKI by age with peaks in older age (≥60 years) and middle childhood (5–15 years), which persisted despite controlling for illness severity, pre-existing comorbidities, or different baseline creatinine estimators. For example, the adjusted OR of developing AKI among hospitalized patients with SARS-CoV2 was 2.74 (95% CI 1.66–4.56) for 10–15-year-olds compared to 30–35-year-olds and similarly was 2.31 (95% CI 1.71–3.12) for 70–75-year-olds, while adjusted OR dropped to 1.39 (95% CI 0.97–2.00) for 40–45-year-olds compared to 30–35-year-olds. Conclusions: SARS-CoV2-related AKI is common with a bimodal age distribution that is not fully explained by known risk factors or confounders. As the pandemic turns to disproportionately impacting younger individuals, this deserves further investigation as the presence of AKI and SARS-CoV2 infection increases hospital mortality risk. © 2022, The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC8831033/bin/12882_2022_2681_MOESM1_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8831033/bin/12882_2022_2681_MOESM2_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8831033/bin/12882_2022_2681_MOESM3_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8831033/bin/12882_2022_2681_MOESM4_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8831033/bin/12882_2022_2681_MOESM5_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8831033/bin/12882_2022_2681_MOESM6_ESM.pdf
Authors & Co-Authors
Bjornstad, Erica C.
United States, Birmingham
The University of Alabama at Birmingham
Cutter, Gary Raymond
United States, Birmingham
The University of Alabama at Birmingham
Menon, Shina
United States, Seattle
Seattle Children's Hospital
St Hill, Catherine A.
United States, Minneapolis
United Hospital, Minneapolis
Banner-Goodspeed, Valerie M.
United States, Boston
Beth Israel Deaconess Medical Center
Christie, Amy B.
Unknown Affiliation
Surapaneni, Krishna Mohan
Unknown Affiliation
Mosier, Jarrod M.
United States, Tucson
University of Arizona College of Medicine – Tucson
Vadgaonkar, Girish
Unknown Affiliation
Walkey, Allan J.
United States, Boston
Boston University Chobanian & Avedisian School of Medicine
Kashyap, Rahul
United States, Rochester
Mayo Clinic
Kumar, Vishakha K.
United States, Mount Prospect
Society of Critical Care Medicine
Bansal, Vikas
United States, Rochester
Mayo Clinic
Boman, Karen
United States, Mount Prospect
Society of Critical Care Medicine
Retford, Lynn
United States, Mount Prospect
Society of Critical Care Medicine
Gajić, Ognjen O.
United States, Rochester
Mayo Clinic
Gist, Katja Michelle
United States, Aurora
University of Colorado Anschutz Medical Campus
Mesland, Jean Baptiste
Unknown Affiliation
Henin, Pierre Y.
Unknown Affiliation
Petre, Hélène
Unknown Affiliation
Buelens, Isabelle
Unknown Affiliation
Gerard, Anne Catherine
Unknown Affiliation
Clevenbergh, Philippe Albert
Unknown Affiliation
Claure-del Granado, Rolando
Unknown Affiliation
Mercado, Jose A.
Unknown Affiliation
Vega-Terrazas, Esdenka
Unknown Affiliation
Iturricha-Cáceres, Maria F.
Unknown Affiliation
Gavidia, Oscar Y.
Unknown Affiliation
Pachon, Felipe
Unknown Affiliation
Sanchez, Yeimy A.
Unknown Affiliation
Knežević, Danijel
Unknown Affiliation
Kovačević, Tanja
Unknown Affiliation
Markić, Joško
Unknown Affiliation
Ardalic, Tatjana Ćatipović
Unknown Affiliation
Polić, Branka
Unknown Affiliation
Ivić, Ivo
Unknown Affiliation
Carev, Dominko
Unknown Affiliation
Glavinić, Robert
Unknown Affiliation
El-Kassas, Mohamed
Unknown Affiliation
Tawheed, Ahmed
Unknown Affiliation
Yahia, Hend
Unknown Affiliation
Kantas, Dimitrios
Unknown Affiliation
Koulouras, Vasilios P.
Unknown Affiliation
Soto, Helin Archaga
Unknown Affiliation
Kopitkó, Csaba
Unknown Affiliation
Bencze, Ágnes
Unknown Affiliation
Méhész, István
Unknown Affiliation
Gerendai, Zsófia
Unknown Affiliation
Doddaga, Phaneendra
Unknown Affiliation
Chandra, Neethi
Unknown Affiliation
Ediga, Rekha
Unknown Affiliation
Basety, Shilpa
Unknown Affiliation
Dammareddy, Shwetha
Unknown Affiliation
Kasumalla, Phani Sreeharsha
Unknown Affiliation
Raju, Umamaheswara
Unknown Affiliation
Manduva, Janaki
Unknown Affiliation
Kolakani, Naresh
Unknown Affiliation
Sripathi, Shreeja
Unknown Affiliation
Chaitanya, Sheetal
Unknown Affiliation
Cherian, Anusha
Unknown Affiliation
Parameswaran, Sreejith
Unknown Affiliation
Parthiban, Magesh
Unknown Affiliation
Menu Priya, A.
Unknown Affiliation
Prabhu, Madhav
Unknown Affiliation
Jakati, Vishal
Unknown Affiliation
Rijhwani, Puneet
Unknown Affiliation
Jain, Ashish
Unknown Affiliation
Gupta, Aviral K.
Unknown Affiliation
Jaiswal, Ram Mohan
Unknown Affiliation
Tyagi, Ambika
Unknown Affiliation
Mathur, Nimish
Unknown Affiliation
Daga, Mradul Kumar
Unknown Affiliation
Agarwal, Munisha
Unknown Affiliation
Rohtagi, Ishan
Unknown Affiliation
Papani, Sridhar
Unknown Affiliation
Kamuram, Mahesh
Unknown Affiliation
Agrawal, Kamlesh Kumar
Unknown Affiliation
Baghel, Vijendra
Unknown Affiliation
Patel, Kirti Kumar
Unknown Affiliation
Jyothisree, Ekambaram
Unknown Affiliation
Petrolwala, Mukur
Unknown Affiliation
Ladva, Bharat
Unknown Affiliation
Itagaki, Yuki
Unknown Affiliation
Suzuki, Reina
Unknown Affiliation
Kyo, Michihito
Unknown Affiliation
Al-Fares, Abdulrahman A.
Unknown Affiliation
Rodríguez-Gutiérrez, René
Unknown Affiliation
Camacho-Ortíz, Adrián
Unknown Affiliation
Hassan-Hanga, Fatimah
Unknown Affiliation
Galadanci, Hadiza Shehu
Unknown Affiliation
Kabara, Halima Salisu
Unknown Affiliation
Amole, Taiwo Gboluwaga
Unknown Affiliation
Kabir, Halima
Unknown Affiliation
Haliru, Dalha Gwarzo
Unknown Affiliation
Asghar, Muhammad Sohaib
Unknown Affiliation
Syed, Mashaal
Unknown Affiliation
Naqvi, Syed Anosh Ali
Unknown Affiliation
Ishaque, Sidra
Unknown Affiliation
Saleem, Ali Faisal
Unknown Affiliation
Siddiqui, Naveed Ur Rehman
Unknown Affiliation
Sherali, Salima
Unknown Affiliation
Hashwani, Yasmin
Unknown Affiliation
Ishaque, Shafia
Unknown Affiliation
Zabolotskikh, Igor B.
Unknown Affiliation
Amer, Marwa Ridha
Unknown Affiliation
Bawazeer, Mohammed Abdullah
Unknown Affiliation
Dahhan, Talal Ibrahim
Unknown Affiliation
Kseibi, Eiad
Unknown Affiliation
Butt, Abid Shahzad
Unknown Affiliation
Khurshid, Syed Moazzum
Unknown Affiliation
Rabee, Muath
Unknown Affiliation
Abujazar, Mohammed Y.M.
Unknown Affiliation
Alghunaim, Razan
Unknown Affiliation
Abualkhair, Maal
Unknown Affiliation
AlFirm, Abeer Turki
Unknown Affiliation
Alamoudi, Razan K.
Unknown Affiliation
AlSharif, Hassan M.
Unknown Affiliation
Almazyad, Mohammed Abdulrahman
Unknown Affiliation
Alarifi, Mohammed Ibrahim
Unknown Affiliation
MacArambon, Jara Mia
Unknown Affiliation
Bukhari, Ahmad Abdullah
Unknown Affiliation
Albahrani, Hussain A.
Unknown Affiliation
Asfina, Kazi Nur
Unknown Affiliation
Aldossary, Kaltham M.
Unknown Affiliation
Gavrilović, Srdjan
Unknown Affiliation
Kovačević, Peđa
Unknown Affiliation
Teruel, Santiago Yus
Unknown Affiliation
Gharpure, Varsha P.
Unknown Affiliation
Raheemi, Usman
Unknown Affiliation
Barry, Suzanne M.
Unknown Affiliation
Woll, Christopher
Unknown Affiliation
Wu, Gregory P.
Unknown Affiliation
Carrole, Erin
Unknown Affiliation
Burke, Kathryn
Unknown Affiliation
Mohammed, Mustafa
Unknown Affiliation
Melamed, Roman R.
Unknown Affiliation
Tierney, David M.
Unknown Affiliation
Patel, Love A.
Unknown Affiliation
Raj, Vino S.
Unknown Affiliation
Dawud, Barite U.
Unknown Affiliation
Mazumder, Narayana
Unknown Affiliation
Sidebottom, Abbey C.
Unknown Affiliation
Guenther, Alena M.
Unknown Affiliation
Krehbiel, Benjamin D.
Unknown Affiliation
Schmitz, Nova J.
Unknown Affiliation
Jepsen, Stacy L.
Unknown Affiliation
Irby, Katherine
Unknown Affiliation
Sanders, Ronald C.
Unknown Affiliation
Hefley, Glenda C.
Unknown Affiliation
Lutrick, Karen
Unknown Affiliation
Campbell, Beth Salvagio
Unknown Affiliation
Wilson, Cathleen
Unknown Affiliation
Rivers, Patrick S.
Unknown Affiliation
Brinks, Jonathan
Unknown Affiliation
Mongoh, Mokenge Ndiva
Unknown Affiliation
Gilson, Boris
Unknown Affiliation
Armaignac, Donna Lee
Unknown Affiliation
Danesh, Valerie C.
Unknown Affiliation
Dubrocq, Gueorgui
Unknown Affiliation
Davis, Amber L.
Unknown Affiliation
Hammers, Marissa J.
Unknown Affiliation
McGahey, Ill M.
Unknown Affiliation
Farris, Amanda C.
Unknown Affiliation
Priest, Elisa Lynne
Unknown Affiliation
Korsmo, Robyn
Unknown Affiliation
Fares, Lorie A.
Unknown Affiliation
Skiles, Kathy
Unknown Affiliation
Shor, Susan M.
Unknown Affiliation
Burns, Kenya
Unknown Affiliation
Gonzales, Gabriela Hope
Unknown Affiliation
Wilk, Debora A.
Unknown Affiliation
Ettlinger, Jason
Unknown Affiliation
Bomar, Jaccallene
Unknown Affiliation
Darji, Himani
Unknown Affiliation
Arróliga, Alejandro C.
Unknown Affiliation
Dowell, Corrie A.
Unknown Affiliation
Khandhar, Paras B.
Unknown Affiliation
Kelly, Lauren E.
Unknown Affiliation
Waikar, Sushrut S.
Unknown Affiliation
DiLorenzo, Madeline A.
Unknown Affiliation
Miller, Aaron Samuel
Unknown Affiliation
Nawathe, Pooja A.
Unknown Affiliation
Tirupathi, Raghavendra
Unknown Affiliation
Green, Cynthia L.
Unknown Affiliation
Sayed, Imran Ali
Unknown Affiliation
Brinton, John T.
Unknown Affiliation
Chiotos, Kathleen
Unknown Affiliation
Blatz, Allison M.
Unknown Affiliation
Cheruku, Sreekanth R.
Unknown Affiliation
Duggal, Abhijit
Unknown Affiliation
Mehkri, Omar
Unknown Affiliation
Dugar, Siddharth Pawan
Unknown Affiliation
Houltham, Stuart
Unknown Affiliation
King, Alexander H.
Unknown Affiliation
Hernández-Montfort, Jaime A.
Unknown Affiliation
Dapul, Heda R.
Unknown Affiliation
Verma, Sourabh
Unknown Affiliation
Gesheff, Martin G.
Unknown Affiliation
Burley, Nicholas B.
Unknown Affiliation
Gupta, Manoj K.
Unknown Affiliation
Oulds, Franscene E.
Unknown Affiliation
Heneghan, Julia A.
Unknown Affiliation
Cartin-Ceba, Rodrigo
Unknown Affiliation
Sen, Ayan
Unknown Affiliation
Tekin, Aysun
Unknown Affiliation
Lal, Amos
Unknown Affiliation
Domecq, Juan Pablo
Unknown Affiliation
Singh, Romil
Unknown Affiliation
Niven, Alexander S.
Unknown Affiliation
Khan, Syed Anjum
Unknown Affiliation
Jain, Nitesh Kumar
Unknown Affiliation
Hamdan, A. Mahmoud
Unknown Affiliation
Sendi, Prithvi
Unknown Affiliation
Totapally, Balagangadhar R.
Unknown Affiliation
Tripathi, Sandeep
Unknown Affiliation
Shoemaker, Jessica
Unknown Affiliation
Mohabir, Paul K.
Unknown Affiliation
Amzuta, Ioana G.
Unknown Affiliation
Gupta, Neha
Unknown Affiliation
Brown, Brent R.
Unknown Affiliation
Bhalala, Utpal S.
Unknown Affiliation
Kuehne, Joshua
Unknown Affiliation
Baram, Michael
Unknown Affiliation
Denson, Joshua Lee
Unknown Affiliation
Moore, Mathew Peter
Unknown Affiliation
Tofil, Nancy M.
Unknown Affiliation
Abusalem, Lana Y.
Unknown Affiliation
Stulce, Casey W.
Unknown Affiliation
McGonagill, Patrick W.
Unknown Affiliation
Chegondi, Madhuradhar
Unknown Affiliation
Cavallazzi, Rodrigo Silva
Unknown Affiliation
Park, Pauline K.
Unknown Affiliation
Wolski, Ann V.
Unknown Affiliation
Camazine, Maraya N.
Unknown Affiliation
Njai, Abdoulie O.
Unknown Affiliation
Ali Shah, Faraaz Ali
Unknown Affiliation
Stapleton, Renee D.
Unknown Affiliation
Akhter, Murtaza
Unknown Affiliation
Gal, Tamas S.
Unknown Affiliation
Karam, Oliver L.
Unknown Affiliation
Khanna, Ashish K.
Unknown Affiliation
Lyons, Patrick G.
Unknown Affiliation
Pattan, Vishwanath
Unknown Affiliation
Statistics
Citations: 7
Authors: 243
Affiliations: 11
Identifiers
Doi:
10.1186/s12882-022-02681-2
ISSN:
14712369
Research Areas
Covid
Health System And Policy
Maternal And Child Health
Violence And Injury
Study Design
Cohort Study