Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
An oral recombinant vaccine in dogs against Echinococcus granulosus, the causative agent of human hydatid disease: A pilot study
PLoS Neglected Tropical Diseases, Volume 2, No. 1, Article e125, Year 2008
Notification
URL copied to clipboard!
Description
Dogs are the main source of human cystic echinococcosis. An oral vaccine would be an important contribution to control programs in endemic countries. We conducted two parallel experimental trials in Morocco and Tunisia of a new oral vaccine candidate against Echinococcus granulosus in 28 dogs. the vaccine was prepaid using two recombinant proteins from adult worms, a tropomyosin (EgTrp) and a fibrillar protein similar to paramyosin (EgA31), cloned and expressed in a live attenuated strain of Salmonella enterica serovar typhimurium. In each country, five dogs were vaccinated with the associated EgA31 and EgTrp; three dogs received only the vector Salmonella; and six dogs were used as different controls. The vaccinated dogs received two oral doses of the vaccine 21 d apart, and were challenged 20 d later with 75,000 living protoscoleces. The controls were challenged under the same conditions. All dogs were sacrified 26-29 d postchallenged, before the appearance of eggs, for safety reasons. We studied the histological response to both the vaccine and control at the level of the duodenum, the natural localization of the cestrode. Here we show a significant decrease of parasite burden in vaccinated dogs (70% to 80%) and a slower development rate in all remaining worms. The Salmonella vaccine EgA31-EgTrp demonstrated a high efficacy against E. granulosus promoting its potential role in reducing transmission to humans and animals. © 2008 Petavy et al.
Authors & Co-Authors
Pétavy, Anne Françoise
France, Lyon
Université de Lyon
Hormaeche, Carlos E.
United Kingdom, Cambridge
University of Cambridge
Lahmar, Samia
Tunisia, Ariana
National Veterinary School
Ouhelli, Hammou
Morocco, Agdal Rabat
Institut Agronimique et Vétérinaire Hassan Ii
Chabalgoity, Jose A.
Uruguay, Montevideo
Universidad de Montevideo
Marchal, T.
France, Lyon
National School of Veterinary Medicine
Azzouz-Maache, Samira
France, Lyon
Université de Lyon
Schreiber, Fernanda
Uruguay, Montevideo
Universidad de Montevideo
Alvite, Gabriela
Uruguay, Montevideo
Universidad de Montevideo
Sarciron, Marie Elisabeth
France, Lyon
Université de Lyon
Maskell, Duncan
United Kingdom, Cambridge
University of Cambridge
Esteves, Adriana
Uruguay, Montevideo
Universidad de Montevideo
Bosquet, Georges
France, Lyon
Université de Lyon
Statistics
Citations: 73
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1371/journal.pntd.0000125
Research Areas
Health System And Policy
Infectious Diseases
Study Locations
Morocco
Tunisia