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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Malignancy risk and Wiedemann-Beckwith syndrome: What follow-up to provide?
Archives de Pediatrie, Volume 15, No. 9, Year 2008
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Description
Wiedemann-Beckwith syndrome (WBS) is a syndrome of excessive growing with a high predisposition to developing embryologic tumours within the first years of life. This risk is evaluated between 7.5 and 10%; it varies with the mechanisms of mutations involved. These take place in two distinct domains of 11p15, which are under parental printing. Emerging techniques of cytogenetic and molecular biology now have shown correlations between genotypes and phenotypes, and can identify the 30% of WBS who are especially at risk of developing tumours. A specific follow-up, integrating the specificity of developing tumours of each 11p15 mutations involved, is now proposed to patients with WBS. © 2008.
Authors & Co-Authors
Santiago, J.
Mayotte, Mamoudzou
Centre Hospitalier de Mayotte
Muszlak, Matthias
Mayotte, Mamoudzou
Centre Hospitalier de Mayotte
Samson, C.
Mayotte, Mamoudzou
Centre Hospitalier de Mayotte
Goulois, E.
Mayotte, Mamoudzou
Centre Hospitalier de Mayotte
Glorion, A.
Mayotte, Mamoudzou
Centre Hospitalier de Mayotte
Atale, Agnès
Mayotte, Mamoudzou
Centre Hospitalier de Mayotte
Ranaivoarivony, V.
Mayotte, Mamoudzou
Centre Hospitalier de Mayotte
Hébert, Jean Christophe
Mayotte, Mamoudzou
Centre Hospitalier de Mayotte
Bouvier, Raymonde J.
France, Lyon
Hopital Edouard Herriot
Cordier, Marie Pierre
France, Bron
Hôpital Femme
Statistics
Citations: 10
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1016/j.arcped.2008.06.009
ISSN:
0929693X
Study Design
Cohort Study