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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Amplification of Plasmodium falciparum multidrug resistance gene 1 in isolates from Gabon
Journal of Infectious Diseases, Volume 192, No. 10, Year 2005
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Description
The study of molecular markers of drug resistance is particularly important in surveillance studies of drugs, such as mefloquine, that still retain efficacy in sub-Saharan Africa yet have encountered resistance elsewhere. In a recent study in Thailand, we identified amplification of the Plasmodium falciparum multidrug resistance gene 1 (pfmdr1) as being the most important predictor of in vitro drug resistance and in vivo failure of mefloquine monotherapy. Here we report amplification of pfmdr1 in >5% of patient samples from Lambaréné, Gabon, collected in 1995. None of the samples collected 7 years later showed pfmdr1 amplification, suggesting that parasites with increased numbers of pfmdr1 copies have not substantially spread through the population. Nevertheless, the detection of multicopy pfmdr1 in African parasites suggests a high potential for rapid selection for resistance, implying that mefloquine use in Africa should be considered only as part of combination therapy. © 2005 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Uhlemann, Anne Catrin
United Kingdom, London
St George’s, University of London
United States, New York
Columbia University Irving Medical Center
Ramharter, Michael
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gabon
Hôpital Albert Schweitzer
Austria, Vienna
Medizinische Universität Wien
Lell, Bertrand
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gabon
Hôpital Albert Schweitzer
Kremsner, Peter G.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gabon
Hôpital Albert Schweitzer
Krishna, Prof Sanjeev
United Kingdom, London
St George’s, University of London
Gabon
Hôpital Albert Schweitzer
Statistics
Citations: 76
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.1086/497337
ISSN:
00221899
Research Areas
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study
Study Locations
Gabon