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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The definition of pneumonia, the assessment of severity, and clinical standardization in the pneumonia etiology research for child health study
Clinical Infectious Diseases, Volume 54, No. SUPPL. 2, Year 2012
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Description
To develop a case definition for the Pneumonia Etiology Research for Child Health (PERCH) project, we sought a widely acceptable classification that was linked to existing pneumonia research and focused on very severe cases. We began with the World Health Organization's classification of severe/very severe pneumonia and refined it through literature reviews and a 2-stage process of expert consultation. PERCH will study hospitalized children, aged 1-59 months, with pneumonia who present with cough or difficulty breathing and have either severe pneumonia (lower chest wall indrawing) or very severe pneumonia (central cyanosis, difficulty breastfeeding/drinking, vomiting everything, convulsions, lethargy, unconsciousness, or head nodding). It will exclude patients with recent hospitalization and children with wheeze whose indrawing resolves after bronchodilator therapy. The PERCH investigators agreed upon standard interpretations of the symptoms and signs. These will be maintained by a clinical standardization monitor who conducts repeated instruction at each site and by recurrent local training and testing. © 2012 The Author.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3297550/bin/supp_54_suppl-2_S109__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3297550/bin/supp_cir1065_Supp_Fig.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3297550/bin/supp_cir1065_4_Scott_Supplementary_Figure_Legends.doc
Authors & Co-Authors
Scott, John Anthony Gerard
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
United Kingdom, Oxford
Nuffield Department of Medicine
Wonodi, Chizoba Barbara
United States, Baltimore
International Vaccine Access Center
Moïsi, Jennifer C.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
United Kingdom, Oxford
Nuffield Department of Medicine
United States, Baltimore
International Vaccine Access Center
Deloria Knoll, Maria
United States, Baltimore
International Vaccine Access Center
Deluca, Andrea N.
United States, Baltimore
International Vaccine Access Center
Karron, Ruth A.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Bhat, Niranjan
United States, Baltimore
International Vaccine Access Center
Murdoch, David Roger
New Zealand, Dunedin
University of Otago
New Zealand, Christchurch
Canterbury Health Laboratories
Crawley, Jane C.
United Kingdom, Oxford
Nuffield Department of Medicine
Levine, Orin S.
United States, Baltimore
International Vaccine Access Center
O'Brien, Katherine L.
United States, Baltimore
International Vaccine Access Center
Feikin, Daniel R.
United States, Baltimore
International Vaccine Access Center
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Statistics
Citations: 185
Authors: 12
Affiliations: 7
Identifiers
Doi:
10.1093/cid/cir1065
ISSN:
10584838
e-ISSN:
15376591
Research Areas
Maternal And Child Health