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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Impact of Zika Virus Emergence in French Guiana: A Large General Population Seroprevalence Survey
Journal of Infectious Diseases, Volume 220, No. 12, Year 2019
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Description
Background: Since the identification of Zika virus (ZIKV) in Brazil in May 2015, the virus has spread throughout the Americas. However, ZIKV burden in the general population in affected countries remains unknown. Methods: We conducted a general population survey in the different communities of French Guiana through individual interviews and serologic survey during June-October 2017. All serum samples were tested for anti-ZIKV immunoglobulin G antibodies using a recombinant antigen-based SGERPAxMap microsphere immunoassay, and some of them were further evaluated through anti-ZIKV microneutralization tests. Results: The overall seroprevalence was estimated at 23.3% (95% confidence interval [CI], 20.9%-25.9%) among 2697 participants, varying from 0% to 45.6% according to municipalities. ZIKV circulated in a large majority of French Guiana but not in the most isolated forest areas. The proportion of reported symptomatic Zika infection was estimated at 25.5% (95% CI, 20.3%-31.4%) in individuals who tested positive for ZIKV. Conclusions: This study described a large-scale representative ZIKV seroprevalence study in South America from the recent 2015-2016 Zika epidemic. Our findings reveal that the majority of the population remains susceptible to ZIKV, which could potentially allow future reintroductions of the virus. © 2019 The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC6834069/bin/jiz396_suppl_supplementary_data.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC6834069/bin/jiz396_suppl_supplementary_material.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC6834069/bin/jiz396_suppl_supplementary_table_s1.docx
Authors & Co-Authors
Bailly, Sarah
French Guiana, Cayenne
Institut Pasteur de la Guyane
Fritzell, Camille
French Guiana, Cayenne
Institut Pasteur de la Guyane
Berthelot, Léna
French Guiana, Cayenne
Institut Pasteur de la Guyane
Vanhomwegen, Jessica
France, Paris
Cnrs Centre National de la Recherche Scientifique
Salje, Henrik
France, Paris
Cnrs Centre National de la Recherche Scientifique
Paireau, Juliette
France, Paris
Cnrs Centre National de la Recherche Scientifique
Mathéus, Séverine
French Guiana, Cayenne
Institut Pasteur de la Guyane
France, Paris
Cnrs Centre National de la Recherche Scientifique
Fernandes-Pellerin, Sandrine
France, Paris
Institut Pasteur, Paris
Djossou, Félix
French Guiana, Cayenne
Centre Hospitalier Andree Rosemon
Carod, Jean François
French Guiana
Centre Hospitalier de L'ouest Guyanais
Kazanji, Mirdad
French Guiana, Cayenne
Institut Pasteur de la Guyane
Manuguerra, Jean Claude
France, Paris
Cnrs Centre National de la Recherche Scientifique
Cauchemez, Simon
France, Paris
Cnrs Centre National de la Recherche Scientifique
Rousset, Dominique
French Guiana, Cayenne
Institut Pasteur de la Guyane
Statistics
Citations: 17
Authors: 14
Affiliations: 5
Identifiers
Doi:
10.1093/infdis/jiz396
ISSN:
00221899
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative