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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Onchocerciasis: The Pre-control Association between Prevalence of Palpable Nodules and Skin Microfilariae
PLoS Neglected Tropical Diseases, Volume 7, No. 4, Article e2168, Year 2013
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Description
Background:The prospect of eliminating onchocerciasis from Africa by mass treatment with ivermectin has been rejuvenated following recent successes in foci in Mali, Nigeria and Senegal. Elimination prospects depend strongly on local transmission conditions and therefore on pre-control infection levels. Pre-control infection levels in Africa have been mapped largely by means of nodule palpation of adult males, a relatively crude method for detecting infection. We investigated how informative pre-control nodule prevalence data are for estimating the pre-control prevalence of microfilariae (mf) in the skin and discuss implications for assessing elimination prospects.Methods and Findings:We analyzed published data on pre-control nodule prevalence in males aged ≥20 years and mf prevalence in the population aged ≥5 years from 148 African villages. A meta-analysis was performed by means of Bayesian hierarchical multivariate logistic regression, accounting for measurement error in mf and nodule prevalence, bioclimatic zones, and other geographical variation. There was a strong positive correlation between nodule prevalence in adult males and mf prevalence in the general population. In the forest-savanna mosaic area, the pattern in nodule and mf prevalence differed significantly from that in the savanna or forest areas.Significance:We provide a tool to convert pre-control nodule prevalence in adult males to mf prevalence in the general population, allowing historical data to be interpreted in terms of elimination prospects and disease burden of onchocerciasis. Furthermore, we identified significant geographical variation in mf prevalence and nodule prevalence patterns warranting further investigation of geographical differences in transmission patterns of onchocerciasis. © 2013 Coffeng et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3623701/bin/pntd.0002168.s001.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3623701/bin/pntd.0002168.s002.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3623701/bin/pntd.0002168.s003.pdf
Authors & Co-Authors
Coffeng, Luc E.
Unknown Affiliation
Pion, Sébastien David Serge
Unknown Affiliation
O'Hanlon, Simon J.
Unknown Affiliation
Cousens, Simon Nicholas
Unknown Affiliation
Abiose, Adenike O.
Unknown Affiliation
Fischer, Peter U.
Unknown Affiliation
Remme, Jan Hans F.
Unknown Affiliation
Dadzie, Kofi Yankum
Unknown Affiliation
Murdoch, Michele E.
Unknown Affiliation
de Vlas, Sake Jan
Unknown Affiliation
Basáñez, María Gloria
Unknown Affiliation
Stolk, Wilma A.
Unknown Affiliation
Boussinesq, Michel
Unknown Affiliation
Statistics
Citations: 35
Authors: 13
Affiliations: 10
Identifiers
Doi:
10.1371/journal.pntd.0002168
ISSN:
19352727
e-ISSN:
19352735
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Systematic review
Study Locations
Mali
Nigeria
Senegal