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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The selective modulation of endothelial cell mobility on RGD peptide containing surfaces by YIGSR peptides
Biomaterials, Volume 26, No. 2, Year 2005
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Description
The ability of the biomimetic peptides YIGSR, PHSRN and RGD to selectively affect adhesion and migration of human microvascular endothelial cells (MVEC) and vascular smooth muscle cells (HVSMC) was evaluated. Cell mobility was quantified by time-lapse video microscopy of single cells migrating on peptide modified surfaces. Polyethylene glycol (PEG) hydrogels modified with YIGSR or PHSRN allowed only limited adhesion and no spreading of MVEC and HVSMC. However, when these peptides were individually combined with the strong cell binding peptide RGD in PEG hydrogels, the YIGSR peptide was found to selectively enhance the migration of MVEC by 25% over that of MVEC on RGD alone (p<0.05). No corresponding effect was observed for HVSMC. This suggests that the desired response of specific cell types to tissue engineering scaffolds could be optimized through a combinatory approach to the use of biomimetic peptides. © 2004 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Fittkau, M. H.
South Africa, Cape Town
University of Cape Town
Zilla, Peter P.
South Africa, Cape Town
University of Cape Town
Bezuidenhout, Deon
South Africa, Cape Town
University of Cape Town
Lutolf, Matthias P.
Switzerland, Zurich
Universität Zürich
Human, Paul A.
South Africa, Cape Town
University of Cape Town
Hubbell, Jeffrey A.
Switzerland, Zurich
Universität Zürich
Davies, Neil Hamer
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 202
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1016/j.biomaterials.2004.02.012
ISSN:
01429612