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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
A quantitative assessment of aorta root rotation in patients with tetralogy of Fallot evaluated by MSCT
Scientific Reports, Volume 11, No. 1, Article 14336, Year 2021
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Description
Lack of conal rotation and conal malseptation is a characteristic anatomical feature for TOF which lead to dextroposed position of aorta and significant RVOT narrowing. The quantitative assessment of these anatomical features using modern cardiac imaging modality has been rarely discussed in the literature. All TOF scanned had in our center from 2013 till 2019 were included. The angle of aortic root rotation was recorded by measuring the angle between a line connecting the midpoint of the non-coronary sinus to the anterior commissure and another line along the interatrial septum. Rotation angles were correlated with proximal main pulmonary artery (MPA) size indexed to BSA. 287 TOF patients were included, 258 patients (91%) had TOF with pulmonary stenosis (TOF-PS) including 138 male (54%), median age 2 years (2 months–40 years), and 29 patients (9%) had TOF with pulmonary atresia (TOF-PA) including 17 male (59%), median age 5 years (1 m-33 years). The whole cases demonstrated clockwise rotation of the aortic root. The mean rotation angle in TOF-PS group was 52.6 ± 20.9° and in TOF-PA group was 64.9 ± 13.9°. Proximal MPA diameter was 11.1 ± 5.9 mm/m2. There was a significant negative correlation between aortic root rotation angle and proximal MPA diameter (r = − 0.262, P = 0.000). The rotation angle of aortic root was significantly higher in TOF-PA compared to TOF-PS (64.9 ± 13.9° vs. 52.6 ± 20.9°, P = 0.001, respectively). MSCT provide a quantitative measurement methodology of conal malseptation and its effect in TOF patients. There is a clockwise rotation angle of the aortic root in TOF patients that correlates negatively with proximal MPA size. TOF-PA have a larger rotation angle of aortic root. © 2021, The Author(s).
Authors & Co-Authors
Romeih, Soha A.
Egypt, Aswan
Aswan Heart Centre
Egypt, Tanta
Tanta University
Kaoud, Alaa
Egypt, Aswan
Faculty of Medicine
HASHEM, Mohamed
Egypt, Asyut
Assiut University
Abdelfattah, Mohamed
Egypt, Aswan
Aswan Heart Centre
Egypt, Cairo
Faculty of Medicine
Gibreel, Mohamed
Egypt, Aswan
Aswan Heart Centre
Elzoghby, Mohamed M.
Egypt, Aswan
Aswan Heart Centre
Egypt, Tanta
Tanta University
Mozy, Wesam El
Egypt, Aswan
Aswan Heart Centre
Egypt, Giza
Cairo University
Statistics
Citations: 1
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1038/s41598-021-93814-4
ISSN:
20452322
Research Areas
Noncommunicable Diseases
Study Approach
Quantitative
Participants Gender
Male