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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Evolution of an influenza pandemic in 13 countries from 5 continents monitored by protein microarray from neonatal screening bloodspots
Journal of Clinical Virology, Volume 61, No. 1, Year 2014
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Description
Background: Because of lack of worldwide standardization of influenza virus surveillance, comparison between countries of impact of a pandemic is challenging. For that, other approaches to allow internationally comparative serosurveys are welcome. Objectives: Here we explore the use of neonatal screening dried blood spots to monitor the trends of the 2009 influenza A (H1N1) pdm virus by the use of a protein microarray. Study design: We contacted colleagues from neonatal screening laboratories and asked for their willingness to participate in a study by testing anonymized neonatal screening bloodspots collected during the course of the pandemic. In total, 7749 dried blood spots from 13 countries in 5 continents where analyzed by using a protein microarray containing HA1 recombinant proteins derived from pandemic influenza A (H1N1) 2009 as well as seasonal influenza viruses. Results: Results confirm the early start of the pandemic with extensive circulation in the US and Canada, when circulation of the new virus was limited in other parts of the world. The data collected from sites in Mexico suggested limited circulation of the virus during the early pandemic phase in this country. In contrast and to our surprise, an increase in seroprevalence early in 2009 was noted in the dataset from Argentina, suggestive of much more widespread circulation of the novel virus in this country than in Mexico. Conclusions: We conclude that this uniform serological testing of samples from a highly standardized screening system offers an interesting opportunity for monitoring population level attack rates of widespread diseases outbreaks and pandemics. © 2014 The Authors.
Authors & Co-Authors
de Bruin, Erwin
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Loeber, J. G.
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Meijer, Adam
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Castillo, G. Martinez
Mexico, Mexico
Spanish Hospital, Mexico City
Cepeda, M. L.Granados
Mexico
Instituto Naciional de Perinatologia
Torres-Sepúlveda, M. Rosario
Mexico, San Nicolas de Los Garza
Universidad Autónoma de Nuevo Leon, Facultad de Medicina
Borrajo, G. J.C.
Argentina, Buenos Aires
Fundación Bioquímica Argentina
Caggana, M.
United States, Albany
New York State Department of Health
Giguére, Yves
Canada, Quebec
Chu de Québec-université Laval
Meyer, M.
South Africa, Potchefstroom
North-west University
Fukushi, M.
Japan, Sapporo
Sapporo City Institute of Public Health
Devi, A. R.Rama
India, Hyderabad
Rainbow Children's Hospital
Khneisser, Issam
Lebanon, Beirut
Université Saint-joseph de Beyrouth
Vilarinho, Laura
Portugal, Porto
National Health Institute Doutor Ricardo Jorge Porto
von Döbeln, U.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Torresani, Toni
Switzerland, Zurich
Universitats-kinderklinik
Mackenzie, John S.
United Kingdom, Glasgow
Royal Hospital for Sick Children
Zutt, I.
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Schipper, Maarten
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Elvers, L. H.
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Koopmans, Marion P.G.
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Netherlands, Rotterdam
Erasmus Mc
Statistics
Citations: 21
Authors: 21
Affiliations: 16
Identifiers
Doi:
10.1016/j.jcv.2014.06.020
ISSN:
13866532
e-ISSN:
18735967
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study