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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Gastric and small bowel ileus after severe burn in rats: The effect of cyclooxygenase-2 inhibitors
Burns, Volume 35, No. 8, Year 2009
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Description
Gastrointestinal (GI) ileus is a common complication after severe burns. Selective cyclooxygenase-2 inhibitors (COX-2i) improved post-operative ileus, but its effect on burn-induced GI dysmotility is unknown. Our aim was to test whether a COX-2i improves gastric emptying (GE) and small bowel transit (SBT) after burn. Experiment on GE: rats were anesthetized and randomized into sham/scald burn, treated/untreated with COX-2i. Six hours after burn, rats received a phenol red meal and were sacrificed 30 min later. Gastric emptying was determined based on the percentage of phenol red recovered in harvested stomachs. Experiment on SBT: rats received a duodenostomy and were scald/sham burned 5 days later. Six hours after burn, rats received a phenol red meal through the duodenostomy catheter and were sacrificed 100 min later. Geometric center (GC) was calculated for SBT. GE was decreased significantly in burned vs. sham animals (p < 0.001). SBT was significantly impaired in burned vs. sham animals (p < 0.001). The COX-2i improved GE in the burn rats but not GE in the control rats or SBT in the burn rats. COX-2i improves burn-induced delayed GE, suggesting the mediation of the latter via the prostaglandin pathway. © 2009.
Authors & Co-Authors
Oliveira, Hermes M.
United States, Galveston
University of Texas Medical Branch, School of Medicine
United States, Galveston
Shriners Burns Institute, Galveston
Brazil, Belo Horizonte
Universidade Federal de Minas Gerais
Sallam, Hanaa S.
United States, Galveston
University of Texas Medical Branch, School of Medicine
Egypt, Ismailia
Faculty of Medicine
Espana-Tenorio, Jonathan
United States, Galveston
University of Texas Medical Branch, School of Medicine
United States, Galveston
Shriners Burns Institute, Galveston
Chinkes, David
United States, Galveston
University of Texas Medical Branch, School of Medicine
United States, Galveston
Shriners Burns Institute, Galveston
Chung, Dai H.
United States, Galveston
University of Texas Medical Branch, School of Medicine
United States, Galveston
Shriners Burns Institute, Galveston
Chen, J. D.Z.
United States, Galveston
University of Texas Medical Branch, School of Medicine
Herndon, David N.
United States, Galveston
University of Texas Medical Branch, School of Medicine
United States, Galveston
Shriners Burns Institute, Galveston
Statistics
Citations: 21
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1016/j.burns.2009.02.022
ISSN:
03054179
Research Areas
Violence And Injury
Study Approach
Quantitative