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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Microdose intravaginal levonorgestrel contraception: A multicentre clinical trial. I. Contraceptive efficacy and side effects
Contraception, Volume 41, No. 2, Year 1990
Notification
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Description
A multicentre clinical trial, including 19 centres in 13 countries, assessed the contraceptive efficacy and clinical acceptability of a Silastic 382 vaginal ring releasing 20 μg of levonorgestrel for at least 90 days. A total of 1005 women entered the study and 8176.74 woman-months of experience was gathered. The rate of intrauterine pregnancy at one year of use was 3.6 per 100 women (95% confidence interval 2.2-5.0), and of ectopic pregnancy, 0.2% (one case). The principal reasons for discontinuation were menstrual disturbances (17.2% at one year), vaginal symptoms (6.0%) and repeated expulsion of the ring (7.1%). The pregnancy rate with this 20 μg levonorgestrel-releasing vaginal ring compares favourably with that of a low estrogen combination oral contraceptive tested by WHO and is less than half that of a progestogen-only oral contraceptive in a WHO randomized study. It is concluded that the WHO intravaginal ring releasing an average of 20 μg of levonorgestrel per 24 hours is an effective method of contraception for at least one year of use. © 1990.
Authors & Co-Authors
World, Health Organization
Unknown Affiliation
Task, F.
Unknown Affiliation
Reproduction,
Unknown Affiliation
Koetsawang, Suporn
Unknown Affiliation
Gao, Ji
Unknown Affiliation
Krishna, U.
Unknown Affiliation
Cuadros, Alvaro
Unknown Affiliation
Dhall, G. I.
Unknown Affiliation
Wyss, R.
Unknown Affiliation
la Puenta, J. Rodriquez
Unknown Affiliation
Andrade, Amaury Teixeira Leite
Unknown Affiliation
Khan, Talat
Unknown Affiliation
Kononova, E. S.
Unknown Affiliation
Lawson, J. P.
Unknown Affiliation
Parekh, U.
Unknown Affiliation
Elstein, Max E.
Unknown Affiliation
Hingorani, V.
Unknown Affiliation
Wang, Na ning
Unknown Affiliation
Yao, Zhong beng
Unknown Affiliation
Landgren, B. M.
Unknown Affiliation
Boukhris, R.
Unknown Affiliation
Lo, Li lan
Unknown Affiliation
Boccard, S.
Unknown Affiliation
Machin, David
Unknown Affiliation
Pinol, Alain P.Y.
Unknown Affiliation
Rowe, P. J.
Unknown Affiliation
Statistics
Citations: 82
Authors: 26
Affiliations: 23
Identifiers
Doi:
10.1016/0010-7824(90)90141-H
ISSN:
00107824
Research Areas
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health
Participants Gender
Female